A Study of NWY001 in Subjects With Advanced Solid Tumors

Chipscreen Biosciences

Status and phase: Enrolling; Phase 1

Conditions: Advanced Solid Tumor

Treatments: Biological: NWY001

Study type: Interventional

Funder types: Industry

Identifiers

NCT05979155

NWY001-101

Details and patient eligibility

About

This is a Phase 1, single-arm, open-label, dose-escalation study in patients with advanced solid tumors including 2 parts:

Part 1: Dose-Escalation Part Part 2: Dose-Expansion Part

Full description

Part 1: Patients with advanced solid tumors that has relapsed from or is refractory to standard therapy or for which no standard therapy exists will be enrolled in different cohorts.

Part 2: Recommended Phase 2 dose (RP2D) of NWY001 will be given to all patients enrolled in this part.

Enrollment: 196 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Willingness to sign a written informed consent document
2. Participant with advanced solid malignant tumor that has relapsed from or is refractory to standard therapy or for which no standard therapy exists
3. 18~75 years of age at the time of screening
4. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
5. Life expectancy ≥3 months
6. Laboratory tests meet the following criteria (no corrective treatment, such as G-CSF, erythropoietin, and blood transfusion, within 14 days before first dose):

1. absolute neutrophil count (ANC) ≥1.5×109/L 2) platelet ≥100×109/L 3) hemoglobin ≥90 g/L 4) creatinine clearance >50 mL/min (according to Cockcroft-Gault equation) 5) both alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤1.5×upper limit of normal (ULN) (≤5×ULN for patients with hepatic metastasis) 6) total bilirubin ≤1.5×ULN (≤3×ULN for patients with gilbert syndrome) 7) international normalized ratio (INR) <2.0, activated partial thromboplastin time (aPTT) ≤1.5×ULN

7. Prior anti-cancer therapy meets the following criteria:

8. major surgery ≥4 weeks

9. radiotherapy ≥4 weeks

10. endocrine therapy ≥2 weeks

11. chemotherapy (including antibody) ≥3 weeks

12. immunotherapy ≥4 weeks

13. At least one measurable target lesion as defined by RECIST1.1

14. For part 2a: Participant has a diagnosis of histologically confirmed advanced (unresectable) or metastatic gastric or gastroesophageal junction adenocarcinoma

15. participant with HER2 overexpression (IHC 3+ or IHC 2+/ISH+) is refractory or intolerant to standard therapy or for which no standard therapy exists. Prior treatment with trastuzumab or HER2-targeted drugs

16. participant with no HER2 expression is refractory or intolerant to standard therapy or for which no standard therapy exists

17. For part 2b: Participant has a diagnosis of histologically confirmed advanced esophageal squamous carcinoma

18. For part 2c: Participant has a diagnosis of histologically confirmed advanced pancreatic ductal adenocarcinoma

19. For part 2d: Participant has a diagnosis of histologically confirmed advanced hepatocellular carcinoma

20. For part 2e: Participant has a diagnosis of histologically confirmed advanced intrahepatic cholangiocarcinoma

21. For part 2f: Participant has a diagnosis of histologically confirmed advanced MSI-H/dMMR colorectal cancer

Exclusion criteria

1. Current or previous history of other active aggressive malignancies in the last 5 years, except :

2. previous history of non-aggressive malignancies, such as cervical carcinoma in situ, melanoma in situ, or ductal carcinoma in situ of the breast that remains in complete remission for years after curative treatment

3. malignancies with negligible risk of metastasis or death (such as adequately treated basal or squamous cell skin cancer and focal prostate cancer)

4. Current or previous history of hematological malignancies

5. Primary central nervous system (CNS) malignancies or CNS metastases

6. History of allergy or hypersensitivity to monoclonal antibodies or excipients, or a known history of allergy to antibodies produced by Chinese hamster ovary cell

7. Uncontrolled infection that requires intravenous antibiotics, antivirals, or antifungal medications

8. History of clinically significant lung diseases (such as interstitial pneumonia, pneumonia, pulmonary fibrosis, and severe radiation pneumonia), or patients suspected of having these diseases on radiographic examination during the screening period

9. Uncontrolled complications, including, but not limited to, persistent active infections, active coagulopathy, uncontrolled cardiovascular disease, uncontrolled immune disease, uncontrolled diabetes, uncontrolled chest and abdominal fluid accumulation, psychiatric disorders that do not meet study requirements, and other serious conditions requiring systemic treatment

10. Known history of HIV, active infections of hepatitis B or hepatitis C

11. Active pulmonary tuberculosis. Participants vaccinated with BCG vaccine may be false positive for PPD, and they could be enrolled if negative for IGRA

12. Women who are pregnant or breastfeeding or intended to become pregnant during the study period

13. Participants of childbearing potential who refuse to take highly effective contraceptive measures during the entire study treatment period and for 120 days after the last dose of study drug

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: None (Open label)

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196 participants in 2 patient groups

Study arm (multiple doses of NWY001)

Experimental group

Description:

Part 1: dose-escalation of monotherapy NWY001

Treatment:

Biological: NWY001

Biological: NWY001

Study arm (RP2D of NWY001)

Experimental group

Description:

Part 2: dose-expansion of monotherapy NWY001

Treatment:

Biological: NWY001

Biological: NWY001