A Study of Oral Vismodegib for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)

Roche

Status and phase

Withdrawn

Phase 2

Conditions

Idiopathic Pulmonary Fibrosis

Treatments

Drug: placebo

Drug: vismodegib

Study type

Interventional

Funder types

Industry

Identifiers

NCT02168530

GB29298

2014-000963-42 (EudraCT Number)

Details and patient eligibility

About

This is a randomized, multicenter, double-blind, placebo-controlled, parallel-group study of vismodegib in patients with IPF. Eligible patients will be randomized in a 2:1 ratio to one of two treatment arms: vismodegib or placebo. The duration of treatment will be 52 weeks. Study drug will be administered daily by the oral route. An 8-week safety follow-up period is included for all patients who receive at least one dose of study drug.

Sex

All

Ages

40+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult patients aged >/=40 years at Visit 1
Diagnosis of IPF within the previous 5 years from time of screening and confirmed at baseline
Patients from countries where a treatment is licensed/approved for IPF must additionally meet at least one of the following criteria to be eligible: (1) be unable to access a licensed therapy for IPF; (2) treatment with a licensed therapy/therapies has been stopped for lack of efficacy or because of safety/tolerability reasons (a washout period will be required); (3) be unwilling to be treated with a licensed therapy and study enrollment considered appropriate.
Forced vital capacity (FVC) >/=40% and </=90% of predicted at screening
Stable baseline lung function as evidenced by a difference of <10% in absolute FVC measurements (in liters) between screening and Day 1/Visit 2 prior to randomization
Diffusion capacity of the lung for carbon dioxide (DLCO) >/=25% of predicted at screening
Adequate hematopoietic capacity, liver and renal function
Female patients of childbearing potential must use two methods of acceptable contraception, including one highly effective method and a barrier method, during treatment and for 7 months after completion of study treatment (or as per local requirement)
Male patients must agree to remain abstinent or use a condom, even after a vasectomy, during sexual intercourse with female partners while being treated with vismodegib/placebo, and for 2 months after completion of study treatment
Agreement not to donate blood or blood products during the study and for at least 7 months (or as per local requirements) after the last dose of study treatment

Exclusion criteria

Pregnant or lactating
Known hypersensitivity to any of the study drug excipients or the drug itself
Prior treatment with vismodegib or any Hh-pathway inhibitor
Evidence of other known causes of interstitial lung disease
Hospitalization due to an exacerbation of IPF within 4 weeks prior to, or during, screening
Lung transplant expected within 12 months of screening
Evidence of clinically significant lung disease other than IPF
Substantial emphysema on high resolution computed tomography (HRCT) with degree of emphysema greater than fibrosis
Post bronchodilator forced expiratory volume in 1 second/FVC ratio <0.7 at screening
Class IV New York Heart Association chronic heart failure or historical evidence of left ventricular ejection fraction <35%
Known current malignancy or current evaluation for a potential malignancy
Known immunodeficiency, including but not limited to HIV infection
Any clinically significant medical disease (other than IPF) that is associated with an expected survival of <12 months, likely to require a change in therapy during the study, or likely to impact the ability of the patient to participate in the study in the opinion of the investigator, or impact the study efficacy or safety assessments