A Study of Pressure Waveform Analysis in Coronary Artery-II

National Taiwan University Hospital Hsin-Chu Branch

Status: Enrolling

Conditions: Ischemic Heart Disease

Treatments: Procedure: CFR and IMR group

Study type: Observational

Funder types: Other

Identifiers

NCT05672706

111-129-E

Details and patient eligibility

About

The goal of this observational study is to test the feasibility of intracoronary adenosine administration during coronary flow reserve(CFR) and index of microcirculatory resistance(IMR) assessment in a population with angina. The main questions it aims to answer are:

• Repeatability of CFR and IMR assessment while hyperemia with intracoronary adenosine was administered.
• Evaluate the correlation of the intrinsic signal of coronary waveform versus physiologic ischemia, while defined by fractional flow reserve(FFR) and CFR respectively.
• The predictive value of FFR, CFR, and IMR on major adverse cardiovascular outcomes in 3 years Participants will undergo FFR, CFR, and IMR assessments in the catheterization laboratory of the National Taiwan University Hospital Hsin-Chu Branch, then clinical events follow up for 3 years.

Enrollment: 30 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants with angina

Exclusion criteria

• Severe valvular heart disease
• History of asthma
• Heart rate less than 50 beats per minute
• systolic blood pressure less than 90 mmHg

Trial design

30 participants in 1 patient group

CFR and IMR group

Treatment:

Procedure: CFR and IMR group