A Study of SCAD Using Stress Contrast Echocardiography

Mayo Clinic

Status: Enrolling

Conditions: Spontaneous Coronary Artery Dissection

Treatments: Procedure: Stress Echocardiography with Contrast

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT07178509

1K23HL155506 (U.S. NIH Grant/Contract)

24-002318

Details and patient eligibility

About

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult >18 years old
• Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history

Exclusion criteria

• Unable to give consent
• Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
• Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
• Pregnant.
• Unable to interrupt breastfeeding.
• Within 3 months of a heart attack.
• Severe aortic stenosis.
• Severe, uncontrolled hypertension (>200/110 mmHg at baseline).

Trial design

50 participants in 2 patient groups

Spontaneous coronary artery dissection (SCAD)

Description:

Subject has a history of spontaneous coronary artery dissection (SCAD)

Treatment:

Procedure: Stress Echocardiography with Contrast

Healthy Subjects

Description:

Subjects are healthy with no significant medical history

Treatment:

Procedure: Stress Echocardiography with Contrast