A Study of the Correlation Between Portal Vein Thrombosis and Prognosis of Liver Transplantation

Ru-zhou Cai

Status: Enrolling

Conditions: Portal Vein Thrombosis

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT06513780

2024-P2-187-01

Details and patient eligibility

About

The goal of this observational study is to investigate the correlation between portal vein thrombosis (PVT) and the prognosis of liver transplantation. The main questions it aims to address are:

What is the prevalence of PVT? What are the risk factors associated with PVT? What is the prognostic impact of preoperative PVT on liver transplantation?

Participants are divided into two groups: the PVT group and the non-PVT group. The investigators will comparatively analyze the data of both groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, and clarify the prognostic effects of PVT.

Full description

The investigators aim to investigate the prevalence and risk factors of PVT, to develop a novel grading or rating system for PVT, and to explore the prognostic impact of preoperative PVT in liver transplantation.

The investigators will:

Recruit patients according to the inclusion/exclusion criteria and obtain signed informed consents. They will collect demographic and laboratory characteristics and classify patients into the PVT group and the non-PVT group based on preoperative ultrasound and/or computed tomography.

Collect patients' perioperative medical imaging, surgical procedures, pathology reports, postoperative treatments, follow-up data, and clinical endpoints.

Comparatively analyze the data of the PVT and non-PVT groups, estimate the prevalence and risk factors of PVT, construct a predictive model for PVT that is applicable in clinical settings, clarify the prognostic effects of PVT, and propose a grading/rating system for PVT.

Enrollment: 700 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Liver transplantation recipients
2. Aged 18 years or older.

Exclusion criteria

1. Retransplantation
2. Multi-organ transplantation
3. Portal vein tumor thrombus

Trial design

700 participants in 2 patient groups

PVT

Description:

Participants who meet the inclusion criteria for portal vein thrombosis prior to liver transplantation

Treatment:

Other: Observation

non-PVT

Description:

Participants who meet the inclusion criteria for the absence of portal vein thrombosis prior to liver transplantation.

Treatment:

Other: Observation