A Study of the Effect of INCB013739 on Cortisone Reducing Enzyme Activity in Obese People Predisposed to Diabetes

Incyte

Status and phase: Completed; Phase 1

Conditions: Insulin Resistance; Obesity

Treatments: Drug: INCB13739

Study type: Interventional

Funder types: Industry

Identifiers

NCT00398619

INCB13739-103

Details and patient eligibility

About

The purpose of this study is to determine whether the investigational drug INCB013739 has an effect on systemic and adipose tissue 11-HSD1 activity in obese, insulin resistant subjects.

Full description

"Proprietary Information: Exploratory (Non-Confirmatory) Trial".

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male and female subjects between 18 years and 65 years of age.
• BMI between 30 and 42 kg/m2, inclusive.
• FPG <126 mg/dL

Exclusion criteria

• Meet criteria for diagnosis of diabetes mellitus at the screening evaluation, female subjects with a history of gestational diabetes are permitted.
• Are receiving oral antidiabetic agents within the 3 months prior to screening.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind