A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure

Rigshospitalet

Status: Completed

Conditions: Acute Liver Failure

Treatments: Procedure: Standard medical treatment; Procedure: High volume plasma exchange

Study type: Interventional

Funder types: Other

Identifiers

NCT00950508

EMPET-001

Details and patient eligibility

About

The aim of this study is to examine if high-volume plasma exchange has a positive effect on mortality in patients with acute liver failure.

Enrollment: 183 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with acute liver failure in encephalopathy grade 2-4

Exclusion criteria

• alcoholic hepatitis
• primary non function liver graft or graft dysfunction
• known chronic liver disease
• known malignancies
• clinical suspicion of brain death

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

183 participants in 2 patient groups, including a placebo group

High volume plasma exchange

Active Comparator group

Description:

3 successive plasma exchanges over 3 days

Treatment:

Procedure: High volume plasma exchange

Procedure: Standard medical treatment

Standard medical treatment

Placebo Comparator group

Treatment:

Procedure: Standard medical treatment