A Study of the Effect of RO4917838 on the QTcF Interval in Healthy Volunteers

Roche

Status and phase

Completed

Phase 1

Conditions

Healthy Volunteer

Treatments

Drug: RO4917838 placebo

Drug: Moxifloxacin

Drug: RO4917838

Study type

Interventional

Funder types

Industry

Identifiers

NCT01613040

2008-001127-57 (EudraCT Number)

BP21705

Details and patient eligibility

About

This multiple-center, multiple-dose, randomized, double-blind, double-dummy, placebo-controlled, positive-controlled, parallel group study will investigate the effect of RO4917838 on the QTc interval in healthy volunteers. Healthy volunteers will be randomized to one of 4 treatment arms; Arm A: low dose of RO4917838, Arm B: high dose of RO4917838, Arm C: placebo to RO4917838 and moxifloxacin on Day 1, Arm D: placebo to RO4917838 and moxifloxacin on Day 11. The anticipated time on study treatment is 11 days.

Enrollment

169 patients

Sex

Male

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy male volunteers aged 18 to 65 years inclusive
Body mass index (BMI) between 18 and 30 kg/m2 inclusive.
Have no contraindications from the following: a detailed medical and surgical history, and a complete physical examination
Able to participate, and willing to give written informed consent and to comply with the study restrictions

Exclusion criteria

History of any clinically significant gastrointestinal, renal, hepatic, broncho-pulmonary, neurological, mental, cardiac, vascular, endocrinological, hematological or allergic disease, metabolic disorder, cancer or cirrhosis.
History of alcohol and/or drug abuse or addiction within the last 2 years prior to Day 1 of the study.
Consumption of nicotine and/or tobacco containing products within the last 3 months prior to Day 1 of the study.
Infection with human immunodeficiency virus, hepatitis B and/or hepatitis C
Any condition or disease detected during the medical interview / physical examination that would render the subject unsuitable for the study, place the subject at undue risk or interfere with the ability of the subject to complete the study in the opinion of the Investigator.
Positive drug screen or alcohol test at screening or prior to enrollment.
Coffee or tea consumption > 10 cups per day or methylxanthine containing drinks >1.5 liter/day or more than 250 g/day of chocolate.
Alcohol consumption averaging > 3 drinks daily