A Study of the Effect of Time-of-day of Training on Chronic Patellar Tendinopathy (TENDOTIME)

Bispebjerg Hospital

Status: Enrolling

Conditions: Jumper's Knee; Tendinopathy

Treatments: Other: Resistance training for knee extensors

Study type: Interventional

Funder types: Other

Identifiers

NCT06217432

TENDOTIME

Details and patient eligibility

About

The study is a 12-week human study where 60 participants with chronic patellar tendinopathy (more than 3 months symptoms duration) are randomised to undergo 12 weeks of targeted resistance exercise either in the morning or in the late afternoon. The overall aim is to investigate when the best time of the day to perform muscular strength training therapy towards tendinopathy is. The study will also include 10 healthy controls who will not perform any exercise training.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sports active men and women
• Age (18-55) years old
• BMI (18.5-30)
• Uni- or bilateral patellar tendinopathy
• Symptom onset >90 days ago

Exclusion criteria

• Patellar tendinopathy longer than 24 months
• Previous surgery in the knee on the ipsilateral side
• Corticosteroid injection in the patellar tendon on the ipsilateral side within the last 6 months
• Any confounding diagnosis to the knee joint
• Known arthritis
• Known diabetes
• Known rheumatic disorders
• Inability to follow rehabilitation or complete follow-ups
• Enrolled in a resistance based-rehabilitation program for the affected patellar tendon within the previous 3 months
• Have an occupation where it is not feasible to avoid pain provoking tasks
• Pregnancy
• Have sleeping disorders or disruptions, e.g., night shift work
• Use of medicines or supplements known to affect collagen synthesis or sleep

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 3 patient groups

Morning exercise

Experimental group

Description:

Three sessions per week of targeted resistance exercise targeting the quadriceps muscles performed between 6:00 and 8:00 for 12 weeks.

Treatment:

Other: Resistance training for knee extensors

Late afternoon exercise

Experimental group

Description:

Three sessions per week of targeted resistance exercise targeting the quadriceps muscles performed between 16:00 and 18:00 for 12 weeks.

Treatment:

Other: Resistance training for knee extensors

Healthy control

No Intervention group

Description:

Healthy individuals without tendinopathy as controls for the transcriptomics and proteomics analyses.