A Study of the Effect of Time-of-day of Training on Chronic Patellar Tendinopathy (TENDOTIME)

B

Bispebjerg Hospital

Status

Enrolling

Conditions

Jumper's Knee
Tendinopathy

Treatments

Other: Resistance training for knee extensors

Study type

Interventional

Funder types

Other

Identifiers

NCT06217432
TENDOTIME

Details and patient eligibility

About

The study is a 12-week human study where 60 participants with chronic patellar tendinopathy (more than 3 months symptoms duration) are randomised to undergo 12 weeks of targeted resistance exercise either in the morning or in the late afternoon. The overall aim is to investigate when the best time of the day to perform muscular strength training therapy towards tendinopathy is. The study will also include 10 healthy controls who will not perform any exercise training.

Enrollment

70 estimated patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Sports active men and women
  • Age (18-55) years old
  • BMI (18.5-30)
  • Uni- or bilateral patellar tendinopathy
  • Symptom onset >90 days ago

Exclusion criteria

  • Patellar tendinopathy longer than 24 months
  • Previous surgery in the knee on the ipsilateral side
  • Corticosteroid injection in the patellar tendon on the ipsilateral side within the last 6 months
  • Any confounding diagnosis to the knee joint
  • Known arthritis
  • Known diabetes
  • Known rheumatic disorders
  • Inability to follow rehabilitation or complete follow-ups
  • Enrolled in a resistance based-rehabilitation program for the affected patellar tendon within the previous 3 months
  • Have an occupation where it is not feasible to avoid pain provoking tasks
  • Pregnancy
  • Have sleeping disorders or disruptions, e.g., night shift work
  • Use of medicines or supplements known to affect collagen synthesis or sleep

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

70 participants in 3 patient groups

Morning exercise
Experimental group
Description:
Three sessions per week of targeted resistance exercise targeting the quadriceps muscles performed between 6:00 and 8:00 for 12 weeks.
Treatment:
Other: Resistance training for knee extensors
Late afternoon exercise
Experimental group
Description:
Three sessions per week of targeted resistance exercise targeting the quadriceps muscles performed between 16:00 and 18:00 for 12 weeks.
Treatment:
Other: Resistance training for knee extensors
Healthy control
No Intervention group
Description:
Healthy individuals without tendinopathy as controls for the transcriptomics and proteomics analyses.

Trial contacts and locations

0

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Central trial contact

Chloé Yeung, PhD

Data sourced from clinicaltrials.gov

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