A Study of the Effects of Multiple Doses of LY3372689 on the Brain in Healthy Participants

Lilly

Status and phase

Completed

Phase 1

Conditions

Healthy

Treatments

Drug: LY3372689

Diagnostic Test: [18F]LSN3316612

Study type

Interventional

Funder types

Industry

Identifiers

NCT04392271

I9X-MC-MTAD (Other Identifier)

17243

Details and patient eligibility

About

This study uses imaging to evaluate how LY3372689 binds to a protein in the brain. This study will be conducted in healthy participants and will last up to about 10 weeks. Screening must be completed within four weeks prior to enrollment.

Enrollment

4 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Overtly healthy males or females who do not have child-bearing potential
Have a body mass index (BMI) of greater than (>)18 to less than or equal to (≤32) kilograms per square meter (kg/m²), inclusive, at screening
Have normal blood pressure, pulse rate, electrocardiogram (ECG, heart tracing), blood and urine laboratory test results that are acceptable for the study
Have venous access sufficient to allow for blood sampling

Exclusion criteria

Have a history of head injury or contraindications to undergoing magnetic resonance imaging (MRI) examination
Are currently participating in or completed a clinical trial within the last 30 days or any other type of medical research judged to be incompatible with this study
Have previously participated or withdrawn from this study
Have had prior participation in other research protocols or clinical care in the preceding year in addition to the radiation exposure expected from participation in this clinical study, such that radiation exposure exceeds the effective dose of 50 milliSievert (mSv), which would be above the acceptable annual limit established by the US Federal Guidelines
Are current smokers or have used tobacco or nicotine-containing products as determined by the cotinine test
Have or used to have health problems or laboratory test results or ECG readings that, in the opinion of the doctor, could make it unsafe to participate or could interfere with understanding the results of the study
Participate in regular vigorous exercise