A Study of the Inflammatory Pathways Associated With Chronic Obstructive Pulmonary Disease Exacerbations

MedImmune

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Study type: Observational

Funder types: Industry

Identifiers

NCT01337661

CD-RI-INDP-1048

Details and patient eligibility

About

The purpose of this study is to observe how the inflammatory pathways differ in subjects with chronic obstructive pulmonary disease (COPD) during an acute exacerbation of COPD (AECOPD).

Full description

This is an observational study in adult male and female subjects with COPD to collect blood, endobronchial tissues and BAL to investigate the inflammatory genes/pathways associated with AECOPD at the time of exacerbation (ie, active disease) and at 6 weeks later (ie, stable disease).

Enrollment: 26 patients

Sex: All

Ages: 40 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Physician-diagnosed acute exacerbations of chronic obstructive pulmonary disease
• Current or ex-smoker with a tobacco history of 15 or more pack years
• Females of childbearing potential must use birth control for the duration of the study.

Exclusion criteria

• Evidence or history of clinically significant disease
• Subjects with asthma
• Subjects taking anti-leukotriene medications

Trial design

26 participants in 1 patient group

COPD subjects

Description:

Adult male and female subjects with COPD