A Study of the Interaction of Rifampin and Vinflunine in Subjects With Advanced Cancer

Bristol-Myers Squibb (BMS)

Status and phase: Withdrawn; Phase 1

Conditions: Cancer

Treatments: Drug: Rifampin; Drug: Vinflunine

Study type: Interventional

Funder types: Industry

Identifiers

NCT00534807

CA183-033

Details and patient eligibility

About

The purpose of this study is to test how vinflunine interacts with rifampin in the human body

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cancer unresponsive to previous treatment
• Consent for genetic samples

Exclusion criteria

• Cancer of the blood
• Spread of cancer to the brain
• Moderate or severe nerve damage
• Low white blood cell counts and platelet counts
• Inadequate liver or kidney function
• Prior treatment with vinflunine
• Use of certain medications that might interfere with the metabolism of vinflunine

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)