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A Study of the Tumor Microenvironment Affecting the Efficacy of Immunotherapy for Esophageal Cancer

W

Wuhan University

Status

Completed

Conditions

Esophageal Cancer

Treatments

Other: no intervention

Study type

Observational

Funder types

Other

Identifiers

NCT06219031
WDRY2024-K007

Details and patient eligibility

About

This study is a retrospective study of clinical specimens. The study subjects were patients with esophageal cancer who received immunotherapy. Tumor tissue specimens surgically removed from patients before treatment will be collected primarily. In situ immunohistochemistry and multicolor immunofluorescence will be performed. We hypothesize that there are differences in lipid metabolism-related proteins in tumor tissues and immune cells in the preexisting tumor microenvironment in patients with esophageal cancer prior to immunotherapy, and that there is a link between such differences and the efficacy of immunotherapy.

Enrollment

22 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Esophageal cancer patients receiving immunotherapy
  2. Radical esophagectomy for esophageal cancer at our institution prior to receiving immunotherapy
  3. Age greater than or equal to 18 years and less than or equal to 75 years old Imaging to assess patient efficacy after cycle 2 immunotherapy (CR/PR, SD/PD according to recist 1.1)
  4. Pathology Tumor tissue available

Exclusion criteria

  1. Clinical and pathologic information not available
  2. Combined history of other malignant tumors
  3. Unavailability of surgically resected tissue
  4. Preoperative neoadjuvant therapy
  5. Radical esophagectomy for esophageal cancer not performed prior to immunotherapy

Trial design

22 participants in 2 patient groups

valid group(CR/PR)
Description:
CR/PR
Treatment:
Other: no intervention
invalid group(SD/PD)
Description:
SD/PD
Treatment:
Other: no intervention

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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