A Study of the Use of Combination of Anti-cholinergic and Minor Tranquilliser in the Treatment of Non-cardiac Chest Pain - a Double Blind Placebo Controlled Study

Hospital Authority, Hong Kong

Status

Unknown

Conditions

Chest Pain

Treatments

Drug: chlordiazepoxide 5 mg, clidinium 2.5 mg, twice daily

Study type

Interventional

Funder types

Other

Identifiers

NCT00516854

HARECCTR0500040

EC1617- 01

Details and patient eligibility

About

Non-cardiac chest pain is a common clinical problem encountered in our practice but at present, the results of treatments are unsatisfactory. The pathogenesis remains unknown but altered motility of the esophagus and psychological factors including anxiety have been implicated as important factors. Reports of the single use of anticholinergic drugs and anxiolytics have yielded conflicting results, has been demonstrated to yield marginal or of no value. However the use of the combination therapy, especially with a double blind fashion have not been reported. On that basis, we propose to use a combination of anti-cholinergic and tranquilliser for the symptomatic treatment of non-cardiac chest pain. The aim of this study is to evaluate the efficacy of combination therapy of anti-cholinergic and anxiolytic drugs in the treatment of non-cardiac chest pain.

Enrollment

100 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Ambulatory patients over the age of 18
Patients who are normal endoscopically
Patients who do not have symptomatic reflux disease
Patient who have normal coronary angiogram or patient with normal exercise radionuclide scan or patient with normal persantin radionuclide scan.

Exclusion criteria

Patients with history of significant cardiac, renal, pulmonary or hepatic diseases,
Patients with history of dyspepsia or peptic ulcer diseases
Patient with documented reflux diseases.
Patient on drugs that affect gastrointestinal motility in the past 2 weeks
Patients who are pregnant or lactating
Patients who are suffering from costochrondritis
Patients who are known to be sensitive to benzodiazepine or anti-cholinergic
Patients with glaucoma and benign prostatic hypertrophy