A Study of Tooth Erosion in People With Esophagogastric Cancer

Memorial Sloan Kettering Cancer Center (MSK)

Status: Enrolling

Conditions: Esophagogastric Cancer

Treatments: Other: Optional Salvia sample; Other: Survey; Other: Intra-oral camera

Study type: Interventional

Funder types: Other

Identifiers

NCT05612048

22-370

Details and patient eligibility

About

The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer, pancreatic cancer, breast cancer, head and neck cancer, or non-small cell lung cancer, or a healthy volunteer.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subject is willing and able to provide written informed consent.
• Patients with a history of esophagogastric, HNSCC, PDAC, CRC, or NSCLC or healthy controls
• Patients must be able to fully comprehend and complete the survey and be willing to have pictures taken of their teeth with a camera or intra-oral camera.
• Patients must be able to understand English language or have access to adequate translation services.
• Age ≥ 18 years old.

Exclusion criteria

• Subjects without evaluable molars or with significant molar dental work precluding dentists from assessing enamel status, Note: evaluable is defined as having bilateral assessable mandibular molars, or erosions present in the remaining assessable quadrants.
• For healthy controls only, patients cannot have a non-skin cancer history nor presenting for a procedure evaluating reflux symptoms.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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300 participants in 3 patient groups

Patients diagnosed with esophagogastric cancer

Experimental group

Description:

Patients have completed the intervention once completing the survey, undergoing dental imaging and future patients will also provide an optional saliva sample.

Treatment:

Other: Intra-oral camera

Other: Survey

Other: Optional Salvia sample

Patients diagnosed with colorectal, pancreatic, breast, head and neck, or non-small cell lung cancer

Experimental group

Description:

Patients undergo consenting and dental imaging during their routine visits at MSK.

Treatment:

Other: Intra-oral camera

Other: Survey

Healthy volunteers who have not been diagnosed with cancer

Experimental group

Description:

Healthy controls will be defined as those without a known or suspected invasive cancer history and excluding those undergoing a procedure for symptomatic reflux.

Treatment:

Other: Intra-oral camera

Other: Survey