A Study of Tumor Imaging With Multispectral Optoacoustic Tomography

Memorial Sloan Kettering Cancer Center (MSK)

Status: Active, not recruiting

Conditions: Breast Cancer; Melanoma

Treatments: Diagnostic Test: Multispectral Optoacoustic Tomography Imaging

Study type: Observational

Funder types: Other

Identifiers

NCT05488483

21-374

Details and patient eligibility

About

Participants in this study will have Multispectral Optoacoustic Tomography/MSOT imaging of both breasts immediately before their ultrasound-guided breast biopsy procedure begins. After the MSO imaging is completed, participation in the study will end.

Enrollment: 12 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participant is a female or male who is 18 years of age or older.

• Participant must meet one of the following:

  • Suspicious breast imaging finding detected on either mammography, ultrasound, or MRI that is visible on ultrasound and therefore recommended for ultrasound-guided breast biopsy (BI-RADS 4 suspicious abnormality; BI-RADS 5, highly suggestive for malignancy)
  • No previous treatment for breast cancer
  • Diagnosis of melanoma

Exclusion criteria

• Life expectancy < 3 months

Trial design

12 participants in 1 patient group

Breast and Melanoma Cohort

Description:

Participants with a suspicious finding at breast ultrasonography (BI-RADS 4 suspicious abnormality; BI-RADS 5, highly suggestive for malignancy) who are scheduled for ultrasound-guided breast biopsy will undergo MSOT imaging of the suspicious breast tumor detected with ultrasound imaging and any additional lesion present in either breast before undergoing ultrasound-guided breast biopsy as the standard of care. We will evaluate MSOT in 10 patients from the Melanoma Surgical Oncology Clinics (Dr. Ariyan, Co-I) with pathologically confirmed ITM following physical exam and biopsy. We will also evaluate MSOT in five melanoma patients with pathologically confirmed IT metastases scheduled for neoadjuvant immunotherapy prior to surgical resection.

Treatment:

Diagnostic Test: Multispectral Optoacoustic Tomography Imaging