A Study of YM155 Plus Docetaxel in Subjects With Stage III (Unresectable) or Stage IV Melanoma

Astellas

Status and phase

Completed

Phase 2

Conditions

Melanoma

Treatments

Drug: YM155

Drug: Docetaxel

Study type

Interventional

Funder types

Industry

Identifiers

NCT01009775

155-CL-034

2009-015738-31 (EudraCT Number)

Details and patient eligibility

About

The purpose of the study is to evaluate survival, response rate, safety and tolerability of YM155 given in combination with docetaxel in subjects with Stage III (unresectable) and Stage IV melanoma.

Full description

All subjects will receive YM155 and docetaxel given in a 21-day cycle. The docetaxel dose will be established based on the findings of the lead-in portion of the study (Part 1). Once the docetaxel dose is established, Part 2 enrollment will begin.

Part 1:

Part 1 is a lead-in stage that will confirm if YM155 can be safely administered in combination with docetaxel at a specified dose.

Part 2:

Subjects enrolled in Part 2 will receive YM155 and docetaxel at the dose established during Part 1.

Enrollment

64 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically or cytologically confirmed Stage III (unresectable) or Stage IV melanoma
No prior systemic treatment or Cytotoxic chemotherapy for advanced melanoma (Stage III or Stage IV)
If the subject is female, she must be non-pregnant and non-lactating at the Baseline Visit. All sexually active males and females of childbearing potential must agree to use an adequate method of contraception throughout the study period
Eastern Cooperative Oncology Group (ECOG) performance status </= 1
Life expectancy > 12 weeks
At least one measurable target lesion according to Response Evaluation Criteria in Solid Tumors ({RECIST} version 1.1)
Subjects with a previous history of non-melanoma malignancy must have undergone curative therapy for all prior malignancies and be considered disease free for at least 5 years

Exclusion criteria

Major surgery within 21 days of the Baseline Visit
Presence or history of brain metastases
Primary ocular, choroidal or mucosal melanoma
Known history of positive test for Hepatitis B surface Antigen (HsbAg) or Hepatitis C antibody or history of positive test for Human Immunodeficiency Virus (HIV)
Hypersensitivity to docetaxel or polysorbate 80
Neuropathy greater than or equal to Grade 2 at Baseline Visit
The subject has been previously treated with YM155
Inadequate marrow, hepatic, and/or renal functions