A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients

Yi Feng, MD

Status: Unknown

Conditions: Flurbiprofen Axetil; Anesthesia, Spinal; Aged; Cerebrospinal Fluid

Study type: Observational

Funder types: Other

Identifiers

NCT04128410

2019PHB169-01

Details and patient eligibility

About

The project will apply the methods of clinical observation experiment to study the central transport characteristics of flurbiprofen axetil by detecting S-flurbiprofen and R-flurbiprofen concentrations in cerebral-spinal fluid(CSF) after intravenous injection of flurbiprofen axetil in elderly patients.

Full description

The patients undergoing spinal anesthesia for lower extremity surgery will be studied. Flurbiprofen axetil 100mg will be injected intravenously. CSF 1ml and blood 2ml will be obtained simultaneously every 5 minutes after intravenous injection in 50 min( T1~T10).CSF and blood samples will be used to detected S-flurbiprofen and R-flurbiprofen concentrations by using Liquid Chromatography-Mass Spectrometry. And the CSF/blood S-flurbiprofen and R-flurbiprofen concentrations ratio were calculated.

Enrollment: 77 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergoing lower extremity surgery under spinal or combined spinal-epidural anesthesia will be selected.

Exclusion criteria

• asthma, liver insufficiency, renal insufficiency, peptic ulcer, allergy to NSAIDs, and a history use of NSAIDs within two weeks before operation.

Trial design

77 participants in 10 patient groups

T1

Description:

At 5 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected

T2

Description:

At 10 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected

T3

Description:

At 15 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected

T4

Description:

At 20 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected

T5

Description:

At 25 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected

T6

Description:

At 30 minutes after flurbiprofen axetil injected intravenously, 14 patients' samples were required to be collected,including 7 younger patients

T7

Description:

At 35 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected

T8

Description:

At 40 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected

T9

Description:

At 45 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected

T10

Description:

At 50 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected