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A Study on Diagnosis and Treatment of End Stage Liver Disease Complicated With Infection (SESLDIR Study)

T

Tongji Hospital

Status

Unknown

Conditions

Infection
End Stage Liver Disease

Treatments

Drug: Antibiotics

Study type

Observational

Funder types

Other

Identifiers

NCT03363451
SESLDIR study

Details and patient eligibility

About

The term of End Stage of Liver Disease (ESLD) was raised in 80's of 20 Century, but without a restrict definition. Infections are the cause and effect in occurrence and development of ESLD, which not only induce or exacerbate ESLD, but also are the most combined complication. Multi-resistant bacteria, multi-organ injury, selection of anti-microbes, supporting treatment, disorder of intestine microbiota, et al are dilemma in clinical practice. Appropriate and formal diagnosis and treatment of ESLD combined infection are imperious nowadays.

Enrollment

2,000 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Decompensation of liver cirrhosis:

  1. ALB <35 g / L; A / G <1.0
  2. TBIL> 35μmol / L;
  3. ALT> 1 × ULN and / or AST> 1 × ULN
  4. PTA <60%
  5. Ascites or hepatic encephalopathy or esophageal variceal bleeding

Acute-on-chronic liver failure:

  1. Chronic liver disease based on: chronic hepatitis or decompensated cirrhosis
  2. onset time: <4 weeks
  3. Hepatic encephalopathy: with or without
  4. Coagulation: PTA ≤ 40% or INR ≥ 1.5
  5. Jaundice: TBIL ≥ 171μmol / L or daily increase ≥ 17.1μmol / L

Chronic liver failure:

  1. The basis of chronic liver disease: decompensated cirrhosis
  2. onset time: -
  3. Hepatic encephalopathy: with or without
  4. Coagulation: PTA ≤ 40% or INR ≥ 1.5 Jaundice: significantly higher

Exclusion criteria

Trial design

2,000 participants in 2 patient groups

Infection Group
Description:
Patients with end stage liver disease with infection
Treatment:
Drug: Antibiotics
Non-infection Group
Description:
Patients with end stage liver disease without infection

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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