A Study on Nutrition Support Therapy of Patients With Liver Failure

Tongji Hospital

Status: Unknown

Conditions: Nutrition

Treatments: Dietary Supplement: standard hospital diet

Study type: Interventional

Funder types: Other

Identifiers

NCT03944330

Nstlf

Details and patient eligibility

About

This study is a Clinical trial to assess the efficacy of nutrition support therapy of patients with liver failure. Patients were randomized to one of 2 groups to receive different nutrition and energy support treatment.

Full description

Patients with liver failure (defined by APASL) induced by any precipitating factors were randomized to two groups; a treatment group and a control group. Participants in treatment group were provided with a standard hospital diet that provided 25-30 kcal/kg/day . Patients in control group receive diet guide

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Male and female patients from 18 to 65 years of age;
2. Patient inclusion criteria: jaundice (serum total bilirubin ≥5 mg/dl) and coagulopathy (INR ≥ 1.5 or prothrombin activity ≥ 40 %), accompanied by ascites and/or encephalopathy within 4 weeks.

Exclusion criteria

1. Surgery with in 4 weeks
2. three degree hepatoencephalopathy
3. malignant tumors
4. cardiac failure or respiratory failure
5. liver transplantation within observing period -

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

a treatment group

Active Comparator group

Description:

All study participants were provided with a standard hospital diet that provided B25-30 kcal/kg/day

Treatment:

Dietary Supplement: standard hospital diet

control group

No Intervention group

Description:

All study participants were not intervened with diet