A Study on the Effect of Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base

Karolinska Institute

Status: Completed

Conditions: Thumb Osteoarthritis

Treatments: Other: PRP; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT04218591

PRP vs placebo

Details and patient eligibility

About

Randomized comparison between Platelet Rich Plasma (PRP) and placebo (Saline) for thumb base.osteoarthritis.

Enrollment: 90 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Arthritis in the thumb base.
• Radiological Eaton Littler class 1-3.
• Clinical signs of thumb base osteoarthritis: pain at palpation of the CMC-1 joint and pain during provocation/grinding test.

Exclusion criteria

• Rheumatoid arthritis.
• Ongoing infection in the hand or wrist.
• History of gout or pseudo gout.
• Inability to co-operate with the follow-up protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction).
• Intra-articular injection in the affected joint within 6 months.
• Eaton Littler class 4 (STT joint involved).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 2 patient groups, including a placebo group

PRP

Active Comparator group

Description:

Intra-articular injection PRP

Treatment:

Other: PRP

Saline

Placebo Comparator group

Description:

Intra-articular injection Saline

Treatment:

Other: Placebo