A Study on the Effectiveness of Laparoscopic Fundoplication on Extraesophageal Manifestations of Gastroesophageal Reflux Disease (GERD)

General Public Hospital Zell am See

Status: Completed

Conditions: Gastroesophageal Reflux Disease (GERD); Extraesophageal Symptoms

Treatments: Procedure: Laparoscopic anti-reflux surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT01324986

Zell 03

Details and patient eligibility

About

Available data regarding the effectiveness of laparoscopic antireflux surgery on extraesophageal symptoms of gastroesophageal reflux disease (GERD) are scarce and mostly controversial. The aim of the present study was to evaluate the clinical effect of partial and total fundoplication on extraesophageal symptoms in a selected cohort of patients with GERD.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• persistent or recurrent symptoms despite continuous medical treatment, at least one typical reflux symptom (heartburn/ regurgitation/dysphagia/epigastric pain) and/or at least one atypical reflux symptom (cough/ asthma/hoarseness/distortion of taste), pathologic esophageal acid exposure as documented by a reflux-related DeMeester score ≥14.7, and symptom correlation ≥50%, and/or reflux episodes >73.

Exclusion criteria

• previous esophageal or gastric surgery, poor physical status (American Society of Anesthesiologists (ASA) scores III and IV) and pregnancy.

Trial design

0 participants in 2 patient groups

Nissen fundoplication

Active Comparator group

Treatment:

Procedure: Laparoscopic anti-reflux surgery

Toupet fundoplication

Active Comparator group

Treatment:

Procedure: Laparoscopic anti-reflux surgery