A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA

Yonsei University

Status: Unknown

Conditions: Helicobacter Pylori Infection; Gastric Ulcer; Stomach Cancer; Duodenal Ulcer

Study type: Observational

Funder types: Other

Identifiers

NCT03057171

4-2015-0146

Details and patient eligibility

About

Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.

Enrollment: 50 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Over 19 years old
2. Patients with gastric ulcer
3. Patients with duodenal ulcer
4. Patients with stomach cancer
5. Patients with gastrointestinal discomfort symptoms

Exclusion criteria

1. Patients who has done helicobacter pylori eradication
2. Patients who has undergone gastrectomy
3. Patients who has undergone endoscopic submucosal dissection
4. Patients with active upper gastrointestinal bleeding

Trial design

50 participants in 4 patient groups

Gastric ulcer

Description:

patients who will undergo EGD for gastric ulcer

Duodenal ulcer

Description:

patients who will undergo EGD for duodenal ulcer

Stomach cancer

Description:

patients who will undergo EGD for stomach cance

health individuals

Description:

patients who will undergo screening EGD