A Study on the Safety and Immunogenicity of Hexavalent Influenza mRNA Vaccine in Adult Participants 50 Years of Age and Older

Sanofi

Status and phase: Enrolling; Phase 2; Phase 1

Conditions: Healthy Volunteers; Influenza

Treatments: Biological: Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1; Biological: Quadrivalent Influenza Vaccine High Dose; Biological: TIV mRNA-neuraminidase (NA); Biological: Quadrivalent Influenza Standard Dose Vaccine; Biological: TIV mRNA-HA Vaccine 2

Study type: Interventional

Funder types: Industry

Identifiers

NCT06744205

FBP00021

U1111-1303-3537 (Registry Identifier)

Details and patient eligibility

About

The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular injection of different formulations of a hexavalent influenza messenger ribonucleic acid (mRNA) vaccine composed of differing dose levels of trivalent (TIV) mRNA hemagglutinin (HA) in combination with TIV mRNA-neuraminidase (NA) compared to an active control ((Fluzone standard-dose quadrivalent influenza vaccine (QIV-SD) or Fluzone high-dose quadrivalent influenza vaccine (QIV-HD) in adults 50 years of age and older.

Full description

Study details include the following:

• Study Duration: approximately 12 months for each participant
• Treatment: 1 injection of hexavalent vaccine, trivalent vaccine, or active control
• Visit frequency: Day (D) 01, D03, D09, D29, and D181; D366 (telephone call)
• Dose escalation with sequential enrollment of sentinel cohorts followed by parallel enrollment of the main cohort

Enrollment: 1,158 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participant aged 50 years on the day of inclusion

• A female participant is eligible to participate if she is not pregnant or breastfeeding and one of the following conditions applies:

  • Is of non-childbearing potential. To be considered of non-childbearing potential, a female must be postmenopausal for at least 1 year, or surgically sterile.

OR

• Is of childbearing potential and agrees to use an effective contraceptive method or abstinence from at least 4 weeks prior to study intervention administration until at least 12 weeks after study intervention administration.

A female participant of childbearing potential must have a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours prior to administration of study intervention.

Exclusion criteria

Participants are not eligible for the study if any of the following criteria are met:

• Known or suspected congenital or acquired immunodeficiency; or receipt of immunosuppressive therapy, such as anti-cancer chemotherapy or radiation therapy, within the preceding 6 months; or long-term systemic corticosteroid therapy (prednisone or equivalent for more than 2 consecutive weeks within the past 3 months)
• Known systemic hypersensitivity to any of the study intervention components (eg, polyethylene glycol, polysorbate); history of a life-threatening reaction to the study interventions used in the study or to a product containing any of the same substances; any allergic reaction (eg, anaphylaxis) after administration of mRNA vaccine
• Previous history of myocarditis, pericarditis, and/or myopericarditis
• Known history of previous episodes of Guillain-Barré syndrome, neuritis (including Bell's palsy), convulsions, encephalitis, transverse myelitis, and vasculitis
• Participants with an electrocardiogram that is consistent with possible myocarditis or pericarditis or, in the opinion of the investigator, demonstrates clinically relevant abnormalities that may affect participant safety or study results
• Self-reported thrombocytopenia, contraindicating intramuscular (IM) vaccination based on Investigator's judgment
• Bleeding disorder, or receipt of anticoagulants in the 3 weeks preceding inclusion, contraindicating IM vaccination based on Investigator's judgment
• Chronic illness that, in the opinion of the Investigator, is at a stage where it might interfere with study conduct or completion
• Moderate or severe acute illness / infection (according to investigator's judgement) or febrile illness (temperature ≥ 38.0°C [≥ 100.4°F]) on the day of vaccination. A prospective participant should not be included in the study until the condition has resolved or the febrile event has subsided.
• Alcohol, prescription drug, or substance abuse that, in the opinion of the Investigator, might interfere with the study conduct or completion
• Participant who had acute infectious symptoms or a positive SARS-CoV-2 RT-PCR or antigen test in the past 10 days prior to the first visit (V01)
• Receipt of any vaccine in the 4 weeks preceding study intervention administration or planned receipt of any vaccine in the 4 weeks following study intervention administration
• Receipt of immune globulins, blood or blood-derived products in the past 3 months
• Previous vaccination against influenza in the previous 6 months with an investigational or marketed vaccine
• Receipt of any mRNA vaccine/product in the 2 months preceding study intervention administration or planned receipt of any mRNA vaccine in the 2 months after study vaccination
• Participation at the time of study enrollment (or in the 4 weeks preceding study intervention administration) or planned participation during the present study period in another clinical study investigating a vaccine, drug, medical device, or medical procedure
• Self-reported or documented seropositivity for human immunodeficiency virus, hepatitis B virus, or hepatitis C virus

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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1,158 participants in 11 patient groups

Group 1 - Hexavalent (Combination 1)

Experimental group

Description:

Participants will receive single dose of hexavalent influenza mRNA vaccine composed of differing dose levels of TIV mRNA-HA Vaccine 1 in combination with TIV mRNA-NA (Combination 1)

Treatment:

Biological: TIV mRNA-neuraminidase (NA)

Biological: Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1

Group 2 - Hexavalent (Combination 2)

Experimental group

Description:

Participants will receive single dose of hexavalent influenza mRNA vaccine composed of differing dose levels of TIV mRNA-HA Vaccine 1 in combination with TIV mRNA-NA (Combination 2)

Treatment:

Biological: TIV mRNA-neuraminidase (NA)

Biological: Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1

Group 3 - Hexavalent (Combination 3)

Experimental group

Description:

Participants will receive single dose of hexavalent influenza mRNA vaccine composed of differing dose levels of TIV mRNA-HA Vaccine 1 in combination with TIV mRNA-NA (Combination 3)

Treatment:

Biological: TIV mRNA-neuraminidase (NA)

Biological: Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1

Group 4 - Hexavalent (Combination 4)

Experimental group

Description:

Participants will receive single dose of hexavalent influenza mRNA vaccine composed of differing dose levels of TIV mRNA-HA Vaccine 1 in combination with TIV mRNA-NA (Combination 4)

Treatment:

Biological: TIV mRNA-neuraminidase (NA)

Biological: Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1

Group 5 - Hexavalent (Combination 5)

Experimental group

Description:

Participants will receive single dose of hexavalent influenza mRNA vaccine composed of differing dose levels of TIV mRNA-HA Vaccine 1 in combination with TIV mRNA-NA (Combination 5)

Treatment:

Biological: TIV mRNA-neuraminidase (NA)

Biological: Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1

Group 6 - Hexavalent (Combination 6)

Experimental group

Description:

Participants will receive single dose of hexavalent influenza mRNA vaccine composed of differing dose levels of TIV mRNA-HA Vaccine 1 in combination with TIV mRNA-NA (Combination 6)

Treatment:

Biological: TIV mRNA-neuraminidase (NA)

Biological: Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1

Group 7 - TIV mRNA-HA Vaccine 1

Experimental group

Description:

Participants will receive a single dose of TIV mRNA-HA Vaccine 1

Treatment:

Biological: Trivalent (TIV) messenger ribonucleic acid (mRNA) hemagglutinin (HA) Vaccine 1

Group 8 - TIV mRNA-NA

Experimental group

Description:

Participants will receive a single dose of TIV mRNA-NA

Treatment:

Biological: TIV mRNA-neuraminidase (NA)

Group 9 - TIV mRNA-HA Vaccine 2

Experimental group

Description:

Participants will receive single dose of TIV mRNA-HA Vaccine 2

Treatment:

Biological: TIV mRNA-HA Vaccine 2

Group 10 - QIV-SD

Active Comparator group

Description:

Participants will receive single dose of QIV-SD vaccine (for participants 50 to 64 years of age only)

Treatment:

Biological: Quadrivalent Influenza Standard Dose Vaccine

Group 11 - QIV-HD

Active Comparator group

Description:

Participants will receive single dose of QIV-HD vaccine

Treatment:

Biological: Quadrivalent Influenza Vaccine High Dose