A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Mayo Clinic

Status: Enrolling

Conditions: Healthy; Spontaneous Coronary Artery Dissection

Treatments: Diagnostic Test: Carotid Ultrasounds; Diagnostic Test: Echocardiogram; Other: Arterial Tonometry; Diagnostic Test: Elastography; Other: Microneurography with sympathoexcitatory maneuvers; Other: Ankle-Brachial Index

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05699200

1K23HL155506 (U.S. NIH Grant/Contract)

21-005636

Details and patient eligibility

About

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Enrollment: 50 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
• For controls: no cardiac disease history

Exclusion criteria

• Pregnancy
• Known or suspected unstable cardiac condition within 4 weeks of the study
• Active treatment with anticoagulation or dual antiplatelet therapy
• Prisoner

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Spontaneous coronary artery dissection (SCAD) group

Other group

Description:

Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.

Treatment:

Other: Ankle-Brachial Index

Other: Microneurography with sympathoexcitatory maneuvers

Diagnostic Test: Elastography

Other: Arterial Tonometry

Diagnostic Test: Echocardiogram

Diagnostic Test: Carotid Ultrasounds

Healthy Control Group

Other group

Description:

Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.

Treatment:

Other: Ankle-Brachial Index

Other: Microneurography with sympathoexcitatory maneuvers

Diagnostic Test: Elastography

Other: Arterial Tonometry

Diagnostic Test: Echocardiogram

Diagnostic Test: Carotid Ultrasounds