A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer (FLORENZA)

AbbVie

Status and phase: Begins enrollment this month; Phase 2

Conditions: Ovarian Cancer

Treatments: Drug: Bevacizumab; Drug: Mirvetuximab Soravtansine; Drug: Carboplatin

Study type: Interventional

Funder types: Industry

Identifiers

NCT07059845

M25-709

2025-521606-18 (Other Identifier)

Details and patient eligibility

About

Ovarian cancer is a lethal disease with an estimated 310,000 new cases and 200,000 deaths experienced worldwide in 2020. The purpose of this study is to assess the adverse events and change in disease activity of mirvetuximab soravtansine with carboplatin, or bevacizumab (Bev), or bev alone in participants with ovarian cancer (OC). Participants must have confirmation of folate receptor alpha (FRa) positivity by the Ventana folate receptor 1 (FOLR1) Assay.

Mirvetuximab Soravtansine (MIRV) is an investigational drug for the treatment of OC. Participants will be assigned to 1 of 2 substudies and further into groups called treatment arms. In substudy 1, arms A-C, participants will receive 1 of 2 doses of MIRV with Bev, or Bev alone. In substudy 2, arms D and E, participants will receive 1 of 2 doses of MIRV with carboplatin, followed by MIRV alone. Approximately 320 participants will be enrolled in the study at 100 sites around the world.

Participants will receive intravenously (IV) infused MIRV with IV infused carboplatin, or IV infused Bev, or IV infused Bev alone. The total study duration will be approximately 40 months.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, and scans.

Enrollment: 320 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Substudy 1 and 2: Confirmed high or medium folate receptor alpha (FRa) expression by Ventana folate receptor 1 (FOLR1) Assay.
• Substudy 1 and 2: Participants must have an Eastern Cooperative Oncology Group performance status of 0 or 1.
• Substudy 1: Participants must have a confirmed diagnosis of Federation of Gynecology and Obstetrics (FIGO) Stage III or IV high-grade serous ovarian, primary peritoneal, or fallopian tube cancer.
• Substudy 1: Tumor must be confirmed HRD test negative (HRP), determined by a local homologous recombination deficient (HRD) test.
• Substudy 2: Participants must have a confirmed diagnosis of high-grade serous ovarian, primary peritoneal, or fallopian tube cancer.
• Substudy 2: Participants must have relapsed after 1 or 2 prior lines of platinum-based chemotherapy.
• Substudy 2: Participants must have platinum-sensitive disease defined as radiographic progression greater than 6 months from the last dose of platinum-based chemotherapy.
• Substudy 2: Participants must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 (assessed by the investigator) at baseline.

Exclusion criteria

• Substudy 1: Participants with progressive disease (PD) while on triplet therapy or after the first day of their last triplet therapy cycle and before randomization.
• Substudy 1: Participants who receive an intervening dose of bevacizumab after the first day of their last triplet therapy cycle and before randomization.
• Substudy 1: Participants who received prior treatment with mirvetuximab soravtansine, any FRα-targeting agent, or any investigational agent.
• Substudy 2: More than 2 prior lines of chemotherapy. Lines of prior anticancer therapy are counted with the following considerations:
• Neoadjuvant +/- adjuvant therapies are considered 1 line of therapy if the neoadjuvant and adjuvant correspond to 1 fully predefined regimen; otherwise, they are counted as 2 prior regimens.
• Maintenance therapy (e.g., bevacizumab, PARP inhibitor) will be considered part of the preceding line of therapy (i.e., not counted independently).
• If a chemotherapeutic agent in a regimen is substituted with another during a course of treatment due to toxicity, it will be considered part of the proceeding line of therapy
• Prior hormonal therapy will not be counted as a separate line of chemotherapy (it will be counted as part of the prior systemic therapy regimen)
• Substudy 2: Participants who received prior treatment with mirvetuximab soravtansine or other FRα-targeting agents.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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320 participants in 5 patient groups

Substudy 1 Arm A: Mirvetuximab Soravtansine (MIRV) Dose A

Experimental group

Description:

Participants will receive dose A of MIRV with bevacizumab (Bev), as part of the approximately 40 month study duration.

Treatment:

Drug: Mirvetuximab Soravtansine

Drug: Bevacizumab

Substudy 1 Arm B: MIRV Dose B

Experimental group

Description:

Participants will receive dose B of MIRV with Bev, as part of the approximately 40 month study duration.

Treatment:

Drug: Mirvetuximab Soravtansine

Drug: Bevacizumab

Substudy 1 Arm C: Bev

Experimental group

Description:

Participants will receive Bev, as part of the approximately 40 month study duration.

Treatment:

Drug: Bevacizumab

Substudy 2 Arm D: MIRV Dose A

Experimental group

Description:

Participants will receive dose A of MIRV with carboplatin, followed by MIRV alone, as part of the approximately 31 month study duration.

Treatment:

Drug: Carboplatin

Drug: Mirvetuximab Soravtansine

Substudy 2 Arm E: MIRV Dose B

Experimental group

Description:

Participants will receive dose B of MIRV with carboplatin, followed by MIRV alone, as part of the approximately 31 month study duration.

Treatment:

Drug: Carboplatin

Drug: Mirvetuximab Soravtansine