A Study to Assess and Compare Safety and Tolerability of 3 Months Treatment With Salbutamol Administered Via MDI Containing Propellant HFA-152a or HFA-134a in Participants ≥ 18 Years of Age With Asthma

GlaxoSmithKline (GSK)

Status and phase

Enrolling

Phase 3

Conditions

Asthma

Treatments

Drug: Salbutamol HFA-152a

Drug: Salbutamol HFA-134a

Study type

Interventional

Funder types

Industry

Identifiers

NCT06261957

220735

2023-509001-76-00 (Other Identifier)

Details and patient eligibility

About

The goal of this study is to assess and compare the safety and tolerability of salbutamol administered via metered dose inhaler (MDI) containing propellant 1,1-difluoroethane (HFA-152a) or 1,1,1,2-tetrafluoroethane (HFA-134a) in participants aged >=18 years with asthma.

Enrollment

412 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Participant of ≥18 years of age at the time of signing the informed consent or written informed consent is obtained from each study participant's legal guardian.
Asthma for ≥ 6 months, defined as:
- Documented history of asthma, as defined by Global Initiative for Asthma (GINA) (GINA, 2023]
- Receiving one of the following asthma treatments, at a stable dose, for at least 12 weeks prior to the screening visit, with treatment that is anticipated to remain stable for the duration of the study:
  - Daily maintenance low to medium dose Inhaled corticosteroid (ICS) (low to medium dose ICS defined as 100-500 μg/day fluticasone propionate or equivalent as defined in the 2023 GINA guidelines [GINA, 2023], plus Short-Acting Beta-2-Adrenoreceptor Agonists (SABA), which is anticipated to remain stable for the duration of the study.
  - Daily maintenance low to medium dose ICS/ Long-acting bronchodilator (LABA) (low to medium dose ICS defined as 100-500 μg/day fluticasone propionate or equivalent as defined in the GINA guidelines [GINA, 2023] plus SABA, which is anticipated to remain stable for the duration of the study.
  - Participants who utilize combination budesonide/formoterol as reliever therapy, whether or not this is in addition to a SABA - are not eligible for screening.
  - Participants who utilize ICS/SABA combination therapy as reliever therapy, in addition to low to medium dose ICS or ICS/LABA as maintenance, are only eligible if they agree to discontinue their ICS/SABA inhaler for the duration of the study (screening through follow-up).
Severity of disease assessed by the investigator by baseline pre-bronchodilator Forced expiratory volume in 1 second (FEV1)
Asthma Control Status
- Asthma Control Questionnaire (ACQ) 6 score <1.5 at screening
- Asthma that has remained stable with no severe exacerbations in the last 6 months. Severe exacerbation defined as:
  - Deterioration of asthma-requiring the use of systemic corticosteroids (tablets, suspension or injection), for at least 3 days, OR
  - An inpatient hospitalization or Emergency Department (ED) visit because of asthma, requiring systemic corticosteroids.
Evidence of reversibility of disease evaluated by pulmonary function testing.
Participants should be able to withhold SABA for ≥6 hours and LABA-containing medications for ≥24 hours for the purposes of performing screening spirometry.

Exclusion criteria

A history of life-threatening asthma or asthma that is unstable in the opinion of the investigator.
Other significant pulmonary diseases to include (but not limited to): pneumothorax, pulmonary fibrotic disease, bronchopulmonary dysplasia, chronic bronchitis, emphysema, chronic obstructive pulmonary disease, tuberculosis or other respiratory abnormalities other than asthma.

espiratory Infection: Culture-documented or suspected bacterial or viral infection of the upper or lower respiratory tract, sinus or middle ear that is not resolved within 4 weeks of screening that led to a change in asthma management, OR in the opinion of the Investigator, is expected to affect the participant's asthma status, OR the participant's ability to participate in the study. 4. Asthma Exacerbation: Any severe asthma exacerbation within 6 months prior to screening.

Current or chronic history of liver disease or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones) 6. Long-acting muscarinic antagonist (LAMA) during the 3 months prior to the start of the study.
Biologic/immunosuppressive therapies used for the treatment of respiratory diseases during the 6 months, or 5 half-lives-whichever is longer-prior to start of the study.