A Study to Assess Benign Joint Hypermobility Syndrome in Children With a History of Wheezing or Asthma

University of Louisville (UOFL)

Status: Completed

Conditions: Benign Joint Hypermobility Syndrome; Wheezing; Asthma

Study type: Observational

Funder types: Other

Identifiers

NCT02163096

14.0447

Details and patient eligibility

About

The purpose of this study is to assess benign joint hypermobility syndrome (BJHS) in children with a history of wheezing or asthma. BJHS is a common syndrome of joint and connective tissue laxity without any other rheumatologic disease. This assessment will be performed by using either method below depending upon if the child has a history of wheezing or severe asthma:

1. Determine the correlation, if there is an increased rate of BJHS in children with a history of wheezing as well as if there is an increased history of wheezing in children with BJHS; or
2. Determine asthma control, lung function and asthma exacerbations (a flare up or acute worsening of symptoms) in children with BJHS compared to children with asthma without BJHS, to assess if it BJHS is associated more with children with severe asthma.

Enrollment: 23 patients

Sex: All

Ages: 6 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All children ages 6-16 with a history of wheezing or asthma

Exclusion criteria

• For subjects with a history of Wheezing: History of chronic lung disease or prematurity, chronic aspiration, congenital anomalies of the upper and lower airway, primary ciliary dyskinesia, cystic fibrosis, history of heart failure, immune deficiency, or any inflammatory arthritis.
• For Subjects with a history of Asthma: current acute respiratory exacerbation, history of chronic lung disease of prematurity, chronic aspiration, congenital anomalies of the upper or lower airway, primary ciliary dyskinesia, cystic fibrosis, restrictive lung disease, history of heart failure, immune deficiency, or inflammatory arthritis.

Trial design

23 participants in 2 patient groups

History of Wheezing, Benign Joint Hypermobility Syndrome

Asthma, Benign Joint Hypermobility Syndrome