A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis (CTROP)

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Status: Completed

Conditions: Osteoporosis; Generalized Chronic Periodontitis

Treatments: Genetic: CTR Gene

Study type: Observational

Funder types: Other

Identifiers

NCT02273128

D129206005

Details and patient eligibility

About

Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.

Full description

Periodontitis is a polymicrobial inflammatory disease which includes various modifiable and nonmodifiable risk factors. The non modifiable risk factors include genetic polymorphisms like metabolism associated genetic polymorphisms ( Vitamin D and Calcitonin).

Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with consequent increase in bone fragility and susceptibility to fractures.

Bone loss is a common feature shared between periodontal disease and osteoporosis.

Out of all genetic factors Calcitonin gene polymorphism contributes to the development of both osteoporosis and chronic periodontitis.

Enrollment: 50 patients

Sex: All

Ages: 35 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male and Female
• Patients aged between 35.00 Year(s) to 60.00 Year(s) diagnosed with Osteoporosis and Chronic Periodontitis who are willing to participate in the study

Exclusion criteria

• Patients who are Systemically compromised and under medications such as steroids.
• Patients who smoke.Pregnant and lactating mothers are excluded from the study

Trial design

50 participants in 1 patient group

CTR Gene in Osteoporosis and Periodontitis

Description:

Patients aged between 35 - 60 yrs with Osteoporosis (BMD\>-2.5) and Chronic Periodontitis (\>3mm Pocket Probing Depth)

Treatment:

Genetic: CTR Gene