A Study to Assess Thymic Function Using PET/CT and MRI

Memorial Sloan Kettering Cancer Center (MSK)

Status: Completed

Conditions: CD34 Selected Peripheral Blood Stem Cell Graft

Treatments: Device: MRI; Device: PET/CT scans

Study type: Observational

Funder types: Other

Identifiers

NCT02909075

16-1244

Details and patient eligibility

About

The purpose of this study is to see if a positron emission tomography/computed tomography (PET/CT) scan and a magnetic resonance imaging (MRI) of the chest can assess changes in the thymus size and function. The researchers would like to monitor the thymus with a PET/CT scan and a MRI before and after the participants transplantation.

Enrollment: 3 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient's age is ≥18 or ≤65 years old.
• Patients must have a plan to receive a CD34-selected peripheral blood stem cell graft.

Exclusion criteria

• Patient is not able to undergo MR imaging due to any contraindication to MRI based on departmental MR questionnaire (e.g. past gadolinium allergies, failure of metallic screening, claustrophobia, inability to lay flat for duration of the study, inability to hold breath, etc.)
• Pregnant or breastfeeding.

Trial design

3 participants in 1 patient group

PET/CT scans and MRI

Description:

Eligible patients will be enrolled onto the study, and will undergo 3 limited field of view (FOV) FDG-PET/CT scans and MRI of the chest: at baseline (within 4 weeks prior to transplantation), and approximately 3 months (+/-2 weeks) and 6 months (+/-2 weeks) after transplant. PET/CT and MR imaging can be completed on the same day. We will also offer the exams on other days if this is easier for the patient. The PET/CT and MR should be performed within 2 weeks of each other.

Treatment:

Device: PET/CT scans

Device: MRI