A Study to Compare Mycophenolate Mofetil and Tacrolimus in the Treatment of Membranous Lupus Nephritis

Hospital Authority, Hong Kong

Status and phase: Completed; Phase 3

Conditions: Glomerulonephritis, Membranous; Lupus Nephritis

Treatments: Drug: prednisolone and mycophenolate mofetil; Drug: prednisolone and tacrolimus

Study type: Interventional

Funder types: Other

Identifiers

NCT00404794

HARECCTR0500003

UW05-205 T/868

Details and patient eligibility

About

This is a prospective randomized open-label pilot study to compare mycophenolate mofetil in combination with corticosteroid treatment and tacrolimus in combination with corticosteroid treatment in membranous lupus nephritis. The change in urine protein excretion will be the primary outcome studied. The study duration will be 24 months for each patient.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• abnormal urine protein excretion and biopsy-proven membranous lupus nephritis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)