A Study to Compare the Effectiveness of Adductor Canal Pain Catheters Following Total Knee Arthroplasty

Mayo Clinic

Status and phase: Completed; Phase 3

Conditions: Osteoarthritis, Knee

Treatments: Drug: Placebo; Drug: Ropivacaine Intermittent Bolus; Drug: Ropivacaine Continuous Infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT05053087

21-000974

Details and patient eligibility

About

The purpose of this research is to study how well the adductor canal pain catheters works after a total knee arthroplasty or replacement of the knee joint. The catheter works by using either an intermittent bolus injection to provide a large dose of medication or continuous infusion of pain medicine, ropivacaine 0.2%, compared to a single-shot adductor canal block.

Enrollment: 60 patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 and ≤ 90 years.
• Willing to participate in the study and competent to provide informed consent.
• Willing to comply with protocol procedures.
• Has an underlying diagnosis of osteoarthritis indicated for a total knee arthroplasty.

Exclusion criteria

• The patient must not have taken any narcotic medications (schedule II) during the 3 months leading up to the surgery.
• The patient must not be allergic or intolerant to a medication used in the multimodal pain pathway.
• Revision knee arthroplasty.
• Uncontrolled diabetes with A1C > 8.0%.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups, including a placebo group

Ropivacaine intermittent bolus

Experimental group

Description:

Subjects will have a catheter placed in the Post Anesthesia Care Unit following clinically indicated surgery with 0.2% ropivacaine dispersed in pulsed intermittent bolus.

Treatment:

Drug: Ropivacaine Intermittent Bolus

Ropivacaine continuous

Experimental group

Description:

Subjects will have a catheter placed in the Post Anesthesia Care Unit following clinically indicated surgery with 0.2% ropivacaine dispersed in a continuous infusion.

Treatment:

Drug: Ropivacaine Continuous Infusion

Single shot adductor canal

Placebo Comparator group

Description:

Subjects will have a catheter placed in the Post Anesthesia Care Unit following clinically indicated surgery with saline.

Treatment:

Drug: Placebo