A Study to Determine the Effectiveness and Tolerability of MK8141 in Patients With High Blood Pressure (MK-8141-006)
Status and phase
Completed
Phase 2
Conditions
Hypertension
Treatments
Drug: Comparator: placebo (unspecified)
Drug: MK8141
Drug: Enalapril
Details and patient eligibility
About
This study will evaluate the effectiveness and tolerability of MK8141 in lowering blood pressure in patients who have hypertension (high blood pressure).
Enrollment
160 patients
Sex
All
Ages
35 to 65 years old
Volunteers
No Healthy Volunteers
Inclusion criteria
- You are 35 to 65 years of age
- In the past 14 days you have not been treated for hypertension
- In the past 14 days you have not taken more than 2 medications to treat high blood pressure
- You are a woman who is not able to have children or do not use birth control
Exclusion criteria
- You are taking more than 2 medications to treat high blood pressure
- You have a history of a stroke, transient ischemic attack (TIA), heart attack, congestive heart failure, coronary artery bypass surgery
- You have Type 1 or 2 diabetes mellitus
- You have an active liver disease, gallbladder disease, or bowel disease
- You are HIV positive
- You have certain types of cancer
- You abuse drug or alcohol
- You have participated in another clinical study in last 4 weeks
Trial design
Primary purpose
Treatment
Allocation
Randomized
Interventional model
Parallel Assignment
Masking
Double Blind
160 participants in 4 patient groups, including a placebo group
1
Experimental group
Description:
Arm 1: Drug 250 mg
Treatment:
Drug: MK8141
2
Experimental group
Description:
Arm 2: Drug 500 mg
Treatment:
Drug: MK8141
3
Active Comparator group
Description:
Arm 3: Active Comparator
Treatment:
Drug: Enalapril
4
Placebo Comparator group
Description:
Arm 4: Pbo Comparator
Treatment:
Drug: Comparator: placebo (unspecified)
Trial contacts and locations
0
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal
© Copyright 2026 Veeva Systems