A Study to Determine the Effectiveness of Utilizing Intraperitoneal Bupivacaine

Metro Health, Michigan

Status: Completed

Conditions: Laparoscopic Appendectomy

Treatments: Drug: Bupivacaine; Drug: Placebos

Study type: Interventional

Funder types: Other

Identifiers

NCT03004222

Appendectomy Study

Details and patient eligibility

About

The purpose of this research is to determine if spraying a local anesthetic to the cecum after a laparoscopic appendectomy decreases the amount of narcotics (pain medicine) needed after surgery and reduces the time to discharge from the hospital.

Full description

The purpose of this study is to determine the effectiveness of using intraperitoneal anesthetic during appendectomy. Subjects will be randomized to receive either 20 mL 0.5% bupivicaine or 20 mL of normal saline (placebo) instilled in the right lower quadrant at the cecum after appendix has been removed. Narcotic consumption will be tracked postoperatively. Hypothesis is that instilling local anesthetic at the cecum during a laparoscopic appendectomy will decrease the amount of narcotic a patient uses postoperatively. Secondarily, this study will attempt to determine if there is a decrease in length of stay for the subjects randomized to the anesthetic infiltration.

Enrollment: 137 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18 years of age and older
• Laparoscopic appendectomy at Metro Health Hospital

Exclusion criteria

• Adults unable to consent Non-English speaking patients
• Suspected or known malignant disease
• Patients with known allergies to the local anesthetic
• Utilizes opioid pain medicine for a chronic condition
• Elective laparoscopic appendectomy
• Known allergy or contraindication to ketorolac

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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137 participants in 2 patient groups, including a placebo group

Local anesthetic (Bupivicaine)

Experimental group

Description:

The experimental arm intervention is 75 subjects will receive the study agent (20 mL of 0.5% bupivacaine) to be sprayed at the cecum after the appendix has been removed and all planned irrigation and aspiration has occurred

Treatment:

Drug: Bupivacaine

Placebo 20 ml

Placebo Comparator group

Description:

75 subjects will be treated with normal saline/placebo to be sprayed at the cecum after the appendix has been removed and all planned irrigation and aspiration has occurred

Treatment:

Drug: Placebos