A Study to Evaluate fMRI of Active DBS Stimulation in Epilepsy

Mayo Clinic

Status: Withdrawn

Conditions: Refractory Epilepsy

Treatments: Diagnostic Test: Functional magnetic resonance imaging (fMRI)

Study type: Interventional

Funder types: Other

Identifiers

NCT04753983

20-006464

Details and patient eligibility

About

The purpose of this study is to use functional imaging to study the mechanisms of the anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS).

Full description

Researchers are testing how changing the settings on deep brain stimulation device (DBS) can help reduce the number and severity of seizures. Functional imaging will be used to study the mechanisms of ANT DBS to optimize the device settings to improve the degree of seizure reduction.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have previously undergone anterior thalamic nucleus deep brain stimulation (DBS) for refractory epilepsy.

Exclusion criteria

• Contraindication to MRI; prior brain resective surgery or large area of brain tissue loss (e.g., large area infarction).

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Anterior Nucleus of the Thalamus (ANT) Deep Brain Stimulation (DBS)

Experimental group

Description:

Subjects that have undergone DBS placement for treatment of refractory epilepsy will undergo a fMRI scan. During the fMRI, the subject will undergo alternating short periods of their DBS in the "on" and "off" state with high- and low frequency settings to measure the brain activation changes induced by the DBS.

Treatment:

Diagnostic Test: Functional magnetic resonance imaging (fMRI)