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This study aims to verify the efficacy and safety of osimertinib in patients with EGFR-sensitive mutation non-small cell lung cancer who progressed after adjuvant targeted therapy following radical surgery. The main questions it aims to answer is: whether EGFR-TKI is effective in the re-treatment of NSCLC after postoperative adjuvant targeted therapy relapse.
Full description
Generic name: Osimertinib mesylate Dosage form: tablets Specifications: 80 mg tablets; 30 tablets/box Usage: Oral, once daily, one tablet at a time Duration of drug administration: until the duration of treatment reaches 3 years, the disease progresses, or other treatment termination criteria are met Primary study endpoint: Objective remission rate evaluated by the investigator (ORR) Secondary study endpoint: Progression-free survival (PFS), duration of response (DoR), disease control rate (DCR), overall survival (OS) and tumor response depth (DepOR) as evaluated by the investigator Safety: Adverse events (AE), clinical laboratory numerical evaluation
Enrollment
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Inclusion criteria
Aged 18 years or older (inclusive).
Histologically confirmed NSCLC (according to the 8th edition of AJCC lung cancer staging standards).
Subjects must be patients with stage IB-IIIB NSCLC after previous radical surgery, who received adjuvant targeted therapy with EGFR TKIs (first-, second-, or third-generation EGFR TKIs) after surgery, and had tumor recurrence and progression more than 3 months after the end of the adjuvant therapy course.
Tumor tissue samples or blood samples previously diagnosed with NSCLC were confirmed to have EGFR sensitive mutations by qualified laboratory tests.
Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1 and no deterioration in the previous 2 weeks, with a minimum expected survival of 12 weeks.
Patients must have at least 1 tumor lesion that can be accurately measured at baseline, with the longest diameter ≥10 mm at baseline (if it is a lymph node, the short diameter must be ≥15 mm). The selected measurement method is suitable for accurate repeated measurements, which can be computed tomography (CT) or magnetic resonance imaging (MRI). If there is only one measurable lesion, it can be accepted as a target lesion, and a baseline evaluation of the tumor lesion must be performed at least 14 days after the diagnostic biopsy.
Within 7 days before treatment, the international normalized ratio (INR) is ≤1.5, or the prothrombin time (PTT) and activated partial thromboplastin time (aPTT) are ≤1.5×ULN.
Women of childbearing age should take appropriate contraceptive measures from screening to 6 months after stopping study treatment and should not breastfeed. Before starting medication, the pregnancy test is negative, or one of the following criteria is met to prove that there is no risk of pregnancy:
Male patients should use barrier contraception (i.e. condoms) from screening to 6 months after stopping study treatment.
The subjects themselves voluntarily participate and sign the informed consent in writing.
Exclusion criteria
Patients who have received any of the following anti-tumor treatments:
a) Patients who have received platinum-containing chemotherapy or other chemotherapy after disease progression; b) Patients who have received other EGFR TKI targeted therapy after disease progression; c) Patients who have received chest radiotherapy after disease progression; d) Patients who have received any lung cancer immunotherapy after disease progression; e) Patients who have received anti-angiogenic drugs such as bevacizumab after disease progression; f) Patients who have received major surgery (including biopsy) or major trauma within 4 weeks before the first administration of the study drug; Patients who are expected to require major surgery during the study; g) Patients who have received more than 30% bone marrow irradiation or large-area radiotherapy within 4 weeks before the first administration of the study drug; i) Patients who have used strong CYP3A4 inhibitors, inducers, or drugs with narrow therapeutic windows that are sensitive substrates of CYP3A4 within 7 days before the first administration of the study drug.
Patients with only local recurrence and who are suitable for radical chest radiotherapy and chemotherapy.
Patients with any complications or other malignancies who require standard treatment or major surgery within 2 years after the first administration of study treatment.
Severe cardiovascular and cerebrovascular diseases, including but not limited to cerebrovascular accident (CVA), transient ischemic attack (TIA), myocardial infarction, unstable angina, heart failure ≥ grade II (New York Heart Association (NYHA) classification) within 6 months before enrollment, and severe arrhythmias (including: requiring drug control during the study; the drugs used will interfere with the normal treatment of the study drugs; arrhythmias that cannot be controlled by drugs).
A history of interstitial lung disease, a history of drug-induced interstitial lung disease, a history of radiation pneumonitis requiring steroid treatment, or any evidence of clinically active interstitial lung disease.
Non-healing wounds, active peptic ulcers, or fractures.
Patients with other malignancies other than non-small cell lung cancer within 5 years before enrollment, excluding fully treated cervical carcinoma in situ, basal cell or squamous cell skin cancer, localized prostate cancer after radical surgery, and breast ductal carcinoma in situ.
Patients with residual toxicity from previous treatment that was greater than CTCAE grade 1 and failed to be relieved at the start of study treatment, excluding those with alopecia and grade 2 neurotoxicity caused by previous chemotherapy.
Spinal cord compression or brain metastasis, unless asymptomatic, stable, and without the need for steroid treatment for at least 2 weeks before the first dose of study treatment.
Patients with any severe or poorly controlled systemic disease, such as active bleeding physique or active infection, as judged by the investigator. Chronic diseases do not need to be screened.
Patients with refractory nausea, vomiting, or chronic gastrointestinal diseases, inability to swallow study drugs, or previous extensive intestinal resection may affect the adequate absorption of osimertinib.
Meet any of the following cardiac examination results:
a) Absolute neutrophil count 2.5 times the upper limit of normal (ULN); if there is liver metastasis, alanine aminotransferase> 5×ULN; e) If there is no clear liver metastasis, aspartate aminotransferase> 2.5×ULN; if there is liver metastasis, aspartate aminotransferase> 5×ULN; f) If there is no clear liver metastasis, total bilirubin> 1.5×ULN; or if Gilbert syndrome (unconjugated hyperbilirubinemia) or liver metastasis exists, total bilirubin> 3×ULN; g) Creatinine> 1.5×ULN and creatinine clearance 1.5×ULN only need to confirm creatinine clearance.
Women who are breastfeeding or have a positive blood or urine pregnancy test within 3 days before the first dose of study treatment.
Patients with proteinuria (urine test strip test) ≥2+ should undergo 24-hour urine collection. Patients are allowed to be enrolled if they show ≤1 g protein within 24 hours, and are not allowed to be enrolled if they show >1g.
History of hypersensitivity to any active or inactive ingredient of osimertinib or to drugs with similar chemical structure to osimertinib or of the same class as osimertinib.
Any severe or uncontrolled eye disease that may increase the patient's safety risk as determined by the doctor.
Patients who may not comply with the study procedures and requirements as determined by the investigator.
Patients who are determined by the investigator to have any condition that endangers patient safety or interferes with study assessments.
Primary purpose
Allocation
Interventional model
Masking
54 participants in 1 patient group
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Central trial contact
Yun Fan; Ying Jin
Data sourced from clinicaltrials.gov
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