A Study to Evaluate the Safety and Immunogenicity of VLP-Polio in Infants and Toddlers

CanSino Biologics

Status and phase: Not yet enrolling; Phase 2; Phase 1

Conditions: Poliomyelitis

Treatments: Biological: VLP-Polio medium dose; Biological: Vaccine Poliomyelitis Inactivated (IPV); Biological: VLP-Polio high dose; Biological: Recombinant Trivalent Poliomyelitis Vaccine (Sf-RVN Cell) (VLP-Polio) low adjuvant dose

Study type: Interventional

Funder types: Industry

Identifiers

NCT06577298

CTP-VLP-002

Details and patient eligibility

About

This is a phase I/II randomized, double-blind, and positive-controlled study. Participants in the phase I toddler group will receive 1 dose of either high dose VLP-Polio (Dose H) or control vaccine in a ratio of 3:1. The phase I infant cohort will have 4 arms randomly assigned to receive either investigational vaccine (Low-adjuvant dose VLP-Polio, Medium dose VLP-Polio, or High dose VLP-Polio or control vaccine in a ratio of 3:1. Phase II infant cohort will have 4 arms randomly assigned to receive either investigational vaccine (Low-adjuvant dose VLP-Polio, Medium dose VLP-Polio, or High dose VLP-Polio or control vaccine in a ratio of 3:1. Each infant participant will be administrated 3 doses of the assigned vaccine with 28 days apart, and the booster dose will be given when the infant is 12-18 months old. Enrollment of Phase I and Phase II will be staggered in descending order of age group but ascending order of dosing levels. Blood and mucosal samples will be collected for immunogenicity evaluation over the time course of the study.

Enrollment: 480 estimated patients

Sex: All

Ages: 6 weeks to 18 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy toddlers aged 12-18 months at the time of screening, and have completed primary immunization of polio vaccine according to the national government program in the first year of life.
• Healthy infants aged 6 weeks to 2 months (42 to 98 days, with the day of birth considered day of life 1), and who have not received any polio vaccines.
• Able to obtain written informed consent from parent(s) or legal guardian(s).
• Participants and their parents or legal guardian(s) can comply with trial procedures, are available for the duration of follow-up, and have a suitable telephone contact available.

Exclusion criteria

Exclusion criteria for the first dose:

• Current polio disease or history of polio disease.
• Toddlers who have an interval of less than 5 months since their last dose of the polio vaccine.
• Infants born at < 37 weeks of gestation.
• Children with a birth weight < 2500g and a body weight < 3500g at the time of enrollment.
• Body temperature ≥37.5°C (the visit may be rescheduled when this criterion is met).
• Have congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc.
• Any moderate or severe acute illness.
• Any abnormal vital signs.
• History of epilepsy, convulsions, or parent with congenital cognitive disability, dementia, or intellectual disabilities.
• Have received immunosuppressive treatment, cytotoxic treatment, glucocorticoid treatment, etc. (excluding local treatment, surface treatment of acute non-concurrent dermatitis, or spray treatment of allergic rhinitis).
• Received or plan to receive blood/plasma products or immunoglobulins throughout the study period or prior to study vaccination.
• History of serious adverse events and/or severe allergic reactions (e.g., systemic allergic reactions) to any component of the study vaccine.
• History of known disturbance of coagulation or blood disorder that could cause anemia or excess bleeding (e.g., thalassemia, coagulation factor deficiencies, severe anemia at birth).
• Immunocompromised individuals with known or suspected immunodeficiency as determined by medical history and/or physical examination (e.g., history of pancreatic, liver, spleen, kidney disease or history of resection).
• Administration of other vaccines within 7 days.
• Participation in other interventional studies within 28 days prior to screening and/or during study participation.
• Household member or sibling who has received or is scheduled to receive OPV in the previous 3 months until 5 weeks after the third dose of the primary immunization series.
• The participant is a direct descendant (child or grandchild) of any person employed by the Sponsor, the contract research organization (CRO), the investigator, or study site personnel.
• History or current evidence of any condition or therapy which might confound the results of the study, interfere with the participant's participation for the full duration of the study, indicate suspected diseases, or is not in the best interest of the participants to participate, in the opinion of the treating investigator.
• Family history of any medical conditions, that in the investigating doctor's opinion, could affect the trial outcomes.
• Any reason or condition the investigator considers sufficient to make a participant ineligible for participation in the study.

Exclusion criteria for the subsequent doses:

• Severe allergic reaction after the previous vaccination.
• Serious adverse events caused by the previous vaccination.
• Newly identified symptoms or newly occurred cases after the first vaccination that do not meet the inclusion criteria for the first dose, or that meet the exclusion criteria for the first dose. The decision to discontinue participation is determined by the investigator.
• Other reasons for exclusion considered by the investigating doctor .

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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480 participants in 14 patient groups

Phase I, Toddler Group A, Experimental vaccine, High dose, IM

Experimental group

Description:

One dose of VLP-Polio on Day 0

Treatment:

Biological: VLP-Polio high dose

Phase I, Toddler Group A, Control vaccine, IM

Active Comparator group

Description:

One dose of IPV control on Day 0

Treatment:

Biological: Vaccine Poliomyelitis Inactivated (IPV)

Phase I, Infant Group B, Experimental vaccine, Low-adjuvant dose, IM

Experimental group

Description:

4 dose of VLP-Polio on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: Recombinant Trivalent Poliomyelitis Vaccine (Sf-RVN Cell) (VLP-Polio) low adjuvant dose

Phase I, Infant Group B, Control vaccine, IM

Active Comparator group

Description:

4 dose of IPV on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: Vaccine Poliomyelitis Inactivated (IPV)

Phase I, Infant Group C, Experimental vaccine, Medium dose, IM

Experimental group

Description:

4 dose of VLP-Polio on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: VLP-Polio medium dose

Phase I, Infant Group C, Control vaccine, IM

Active Comparator group

Description:

4 dose of IPV on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: Vaccine Poliomyelitis Inactivated (IPV)

Phase I, Infant Group D, Experimental vaccine, High dose, IM

Experimental group

Description:

4 dose of VLP-Polio on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: VLP-Polio high dose

Phase I, Infant Group D, Control vaccine, IM

Active Comparator group

Description:

4 dose of IPV on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: Vaccine Poliomyelitis Inactivated (IPV)

Phase II, Infant Group E, Experimental vaccine, Low-adjuvant dose, IM

Experimental group

Description:

4 dose of VLP-Polio on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: Recombinant Trivalent Poliomyelitis Vaccine (Sf-RVN Cell) (VLP-Polio) low adjuvant dose

Phase II, Infant Group E, Control vaccine, IM

Active Comparator group

Description:

4 dose of IPV vaccine on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: Vaccine Poliomyelitis Inactivated (IPV)

Phase II, Infant Group F, Experimental vaccine, Medium dose, IM

Experimental group

Description:

4 dose of VLP-Polio on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: VLP-Polio medium dose

Phase II, Infant Group F, Control vaccine, IM

Active Comparator group

Description:

4 dose of IPV on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: Vaccine Poliomyelitis Inactivated (IPV)

Phase II, Infant Group G, Experimental vaccine, High dose, IM

Experimental group

Description:

4 dose of VLP-Polio on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: VLP-Polio high dose

Phase II, Infant Group G, Control vaccine, IM

Active Comparator group

Description:

4 dose of IPV on Day 0, Day 28, Day 56 and Month 12-18 of age

Treatment:

Biological: Vaccine Poliomyelitis Inactivated (IPV)