Status and phase
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About
The purpose of this study is to evaluate the safety and immunogenicity of the investigational medicinal product, CVI-HBV-002.
Full description
A Randomized, Open-labelled, Parallel, Phase 1 clinical study to evaluate the safety, reactogenicity and immunogenicity of the hepatitis B vaccine CVI-HBV-002 in adults
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Exclusion criteria
Patient with positive test for antibody to hepatitis B core antigen (anti-HBc)
Acute illness and/or fever (tympanic temperature rises greater than 38 degrees Celsius) within 72 hours before administration of investigational product
A person who suffered from serious acute or chronic infection within 7 days prior to administration of investigational product (Those who need systemic antibiotic treatment or antiviral therapy)
In case of immunodeficiency or immune dysfunction, or if there is a family history of such
Patients with abnormal liver function test results
Patients with active bacterial, viral or fungal infections requiring systemic treatment
Patients with a history of serious heart disease (NYHA Functional Class III or IV heart failure, myocardial infarction within 6 months, ventricular tachyarrhythmias requiring treatment, or unstable angina, etc.)
Seizure disorders requiring anticonvulsant treatment
Patients with severe chronic obstructive pulmonary disease accompanied by hypoxemia
Patients with uncontrolled diabetes
Patients with uncontrolled hypertension
Patient with positive test for HBsAg, HIV or Hepatitis C
Those with hypersensitivity or anaphylactic reaction to HBV vaccine components
Those who have received immunosuppressive or immunomodulatory drugs within 6 months before screening
Patients who have received high-dose (20 mg or more per day based on prednisolone*) systemic corticosteroids for a long period of time (administration for more than 14 consecutive days) within 3 months before screening (in the case of topical corticosteroids, subject to the investigator's judgment)
* Equivalent to cortisone 125 mg, hydrocortisone 100 mg, prednisone 20 mg, methylprednisolone 16 mg, triamcinolone 16 mg, dexamethasone 3 mg, betamethasone 2.4 mg
Patients currently undergoing hemodialysis
In case of continuous drinking (more than 21 units/week, 1 unit (1 cup) = 10g of pure alcohol) or alcohol dependence
In addition to the above, those who have clinically significant findings that are considered inappropriate for this study based on medical judgment by the principal investigator or person in charge
Pregnant or lactating women or self- and partner contraception during clinical trials (e.g., sterilization, intrauterine contraceptives, oral contraceptives in combination with interstitial barrier contraception, other hormone delivery systems in combination with interstitial barrier contraception, contraceptive cream, jelly or foam) Persons who cannot agree on diaphragms or condoms)
Patients who are concerned about the decline in daily function due to mental illness or who cannot understand the purpose and method of this clinical trial
Those who may show other serious febrile or systemic reactions
Those who are scheduled to participate in other clinical trials after being enrolled in this clinical trial, or who have participated in other clinical trials within 3 months before being enrolled in this clinical trial
Those who are considered difficult to conduct this clinical trial when judged by other investigators
Primary purpose
Allocation
Interventional model
Masking
30 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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