A Study to Evaluate the Use of a Graded Infusion of Intravenous Glucose in the Assessment of Insulin Secretion Rates (MK-0000-078)

Merck Sharp & Dohme (MSD)

Status and phase: Completed; Phase 1

Conditions: Healthy

Treatments: Procedure: Comparator: graded infusion of intravenous glucose

Study type: Interventional

Funder types: Industry

Identifiers

NCT01021462

0000-078

078

2009_695

Details and patient eligibility

About

A two period pilot study to determine if a graded glucose infusion using a glucose (20% dextrose [D20]) intravenous infusion can be properly implemented and will be well tolerated in healthy subjects.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subject is in good health
• Subject is a non-smoker

Exclusion criteria

• Subject has a history of hypertension requiring treatment
• Subject has a history of cancer
• Subject's parents of siblings have a history of type 2 diabetes
• Subject is unable to refrain from the use of any prescription or non-prescription medication
• Subject consumes excessive amounts of alcohol or caffeine
• Subject has had major surgery, donated blood or participated in another investigational study in the past 4 weeks

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Period 1 + Period 2

Experimental group

Description:

graded infusion of intravenous glucose

Treatment:

Procedure: Comparator: graded infusion of intravenous glucose