A Study to Investigate the Pharmacodynamic Effects of CT327 on Intra-dermal Nerve Growth Factor (NGF) and Evoked Pain Responses, in Healthy Male Volunteers

Creabilis

Status and phase

Completed

Phase 1

Conditions

Neuropathic Pain

Treatments

Drug: CT327 (or placebo) followed by placebo (or CT327)

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01243307

CT327-1002

Details and patient eligibility

About

The primary objective of this study is to compare the effect of CT327 to placebo against experimental induced superficial, deep and hyperalgesic pain.

The secondary objectives are to elucidate the mechanisms of CT327 using experimental pain models.

Enrollment

24 estimated patients

Sex

Male

Ages

18 to 64 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Subjects must be able to understand the contents of the study, comply with the study and willing to sign informed consent
Subjects must be free from clinically significant illness or disease as determined by their medical history, physical examination, laboratory and other tests
All male subjects must take adequate contraceptive precautions during the course of the study and for 30 days after their participation in the study has ended

Exclusion criteria

Participation in other clinical studies within 3 months before screening
Scheduled for surgery, medical treatment or any hospital admission that would fall within the study
Use of strong painkillers
Use of any analgesic within 24 hours before start of study
Use of a regular course of prescribed medication and/or herbal medicine
The presence of lesions, significant scars, cuts, wounds, dermal abnormalities, tattoos or naevi in the test areas
A past history of contact dermatitis, psoriasis or keloid
Any clinically significant ECG abnormality at screening
A history of drug or other allergy that contraindicates his participation.
Regular or average consumption of more than 21 units of alcohol per week (one unit of alcohol equals approximately 250 mL of beer, 125 mL of wine or 20 mL of spirits).
Smokes more than five cigarettes (on average) per day, or had been a smoker of more than 5 cigarettes (on average) per day within the 3 months prior to screening.
A known history of drug or alcohol abuse.
As a result of the medical screening process, the PI or medical delegate considers the subject unfit for the study.
Use of any prescription medication within 2 weeks or 5 half-lives (whichever is longer) of dosing.
Use of non-prescription medication (e.g. aspirin, vitamins and herbal and dietary supplements) within 7 days prior to dosing, or 14 days if the medication contained grapefruit/ grapefruit juice or St John's Wort.