ClinicalTrials.Veeva

Menu
The trial is taking place at:
A

Alliance for Multispecialty Research, LLC. | New Orleans, LA

Veeva-enabled site

A Study to Learn About the Safety and Immune Response of a New Pneumococcal Vaccine in Adults

Pfizer logo

Pfizer

Status and phase

Active, not recruiting
Phase 2
Phase 1

Conditions

Pneumococcal Disease

Treatments

Biological: 20-valent pneumococcal conjugate vaccine (20vPnC)
Biological: Multivalent Pneumococcal Vaccine - Formulation 2
Biological: Multivalent Pneumococcal Vaccine - Formulation 1

Study type

Interventional

Funder types

Industry

Identifiers

NCT06182124
C4931001

Details and patient eligibility

About

The purpose of this study is to learn about the safety and immune effects of a pneumococcal vaccine in adults. This vaccine can possibly provide protection against further pneumococcal disease.

This study will happen in in 2 stages: Stage 1 is seeking participants who are between 18 years to 49 years of age. The participants will receive 1 of 2 pneumococcal vaccine candidates (different formulations) or 20vPnC (Prevnar 20) as a single shot given into the upper arm muscle.

Stage 2 will begin after participants have completed Stage 1, and a pneumococcal vaccine candidate has been decided.

Stage 2 is seeking participants who are adults 50 years of age and older. The participants will receive the chosen pneumococcal vaccine candidate from Stage 1 or 20vPnC (Prevnar 20). The vaccines will be given as a single shot into the upper arm muscle.

Participants will take part in this study for about 6 months for Stage 1 and 12 months for Stage 2. During this time participants will have from 2 to 4 clinic visits and 1 phone visit. At these clinic visits, participants will be asked if any side effects were experienced. The participants will also have to give blood samples during these clinic visits.

Enrollment

703 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Male or female participants ≥18 to<50 years of age (Stage 1) and ≥50 years of age (Stage 2) at the time of consent
  • Adults determined by clinical assessment to be eligible for the study, including adults with preexisting stable disease within 12 weeks before receipt of study intervention
  • Participants willing to use acceptable contraception for at least 28 days after study intervention; female participants not of childbearing potential; male participants unable to father children
  • Phase 1 (Stage 1): Adults 18 through 49 years of age with no history of ever receiving a pneumococcal vaccine (ie, pneumococcal vaccine-naïve)
  • Phase 2 (Stage 2): Adults ≥50 through 64 years of age with no history of ever receiving a pneumococcal vaccine (ie, pneumococcal vaccine-naïve) and adults 65 years of age and older with either no history of ever receiving a pneumococcal vaccine or who received PPSV23 >5 years prior to the first vaccination in this study (ie, experienced)

Exclusion criteria

  • History of severe adverse reaction associated with a vaccine and/or severe allergic reaction to any component in pneumococcal conjugate vaccines and any other diphtheria toxoid-containing vaccine
  • Serious chronic disorder that in the investigator's opinion would make the participant inappropriate for entry into the study
  • Medical or psychiatric condition (recent or active suicidal ideation/behavior or laboratory abnormality) that may increase risk of study participation or make participant inappropriate for the study
  • Known or suspected immunodeficiency or other conditions associated with immunosuppression
  • Planned receipt of any licensed or investigational pneumococcal vaccine, or planned receipt of any licensed or investigational pneumococcal vaccine through study participation
  • Receipt of any inactivated or otherwise nonlive vaccine within 14 days or any live vaccine within 28 days before administration of study intervention

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

703 participants in 3 patient groups

Phase 1 (Stage 1): Multivalent Pneumococcal Vaccine - Formulation 1
Experimental group
Description:
Participants to receive a single injection of Multivalent Pneumococcal Vaccine - Formulation 1. This is a possible candidate for continuation in Phase 2 (Stage 2).
Treatment:
Biological: Multivalent Pneumococcal Vaccine - Formulation 1
Phase 1 (Stage 1): Multivalent Pneumococcal Vaccine - Formulation 2
Experimental group
Description:
Participants to receive a single injection of Multivalent Pneumococcal Vaccine - Formulation 2. This is a possible candidate for continuation in Phase 2 (Stage 2).
Treatment:
Biological: Multivalent Pneumococcal Vaccine - Formulation 2
Phase 1 (Stage 1) and Phase 2 (Stage 2): 20-valent pneumococcal conjugate vaccine (20vPnC)
Active Comparator group
Description:
Participants to receive a single injection of 20vPnC.
Treatment:
Biological: 20-valent pneumococcal conjugate vaccine (20vPnC)

Trial contacts and locations

17

Loading...

Central trial contact

Pfizer CT.gov Call Center

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems