A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)

National University Health System (NUHS)

Status: Unknown

Conditions: Spine Metastasis

Treatments: Radiation: Stereotactic body radiotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT03072979

2016/01179

Details and patient eligibility

About

Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy

Enrollment: 18 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥21 years of age
• Proven metastatic disease, excluding haematological and germ cell neoplasms
• Life expectancy >3 months, Eastern Cooperative Oncology group (ECOG) 0-2

Exclusion criteria

• The patient must not have an allergy to gadolinium contrast that will limit the ability to image the tumour by MRI safely even with the use of premedication
• eGFR < 30 mL/min or if patient is suffering from acute renal insufficiency
• Prior radiotherapy to the specified region
• Recent surgery to affected spinal levels, or patients requiring immediate surgical intervention
• Spinal instability score (SINS) >12
• Symptomatic cord compression (Bilksy grade 2 or 3), or worsening neurological deficits
• Body weight of more than 120kg
• Pregnancy