A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome

Hospital Universiti Sains Malaysia

Status: Enrolling

Conditions: Carpal Tunnel Syndrome

Treatments: Dietary Supplement: Alpha-Lipoic Acid, Vitamin E, and Vitamin B Complex; Dietary Supplement: combination vitamin b1,b6 b12

Study type: Interventional

Funder types: Other

Identifiers

NCT07312123

USM/JEPeM/KK/25060535

NMRR ID-25-01261-KS3 (Other Identifier)

Details and patient eligibility

About

Carpal Tunnel Syndrome (CTS) is a common condition that causes numbness, tingling, pain, and weakness in the hand due to compression of the median nerve at the wrist. It can affect daily activities, work performance, and quality of life. While surgery is effective in severe cases, many patients with mild to moderate CTS are initially treated with non-surgical options such as splinting and medications. However, the effectiveness of oral supplements for CTS remains uncertain.

This clinical study aims to evaluate whether an oral combination of alpha-lipoic acid, Vitamin E, and Vitamin B complex can safely reduce symptoms and improve hand function in patients with Carpal Tunnel Syndrome. These supplements are believed to have antioxidant, anti-inflammatory, and nerve-protective properties, which may help reduce nerve irritation and improve nerve recovery.

Participants in this study will be randomly assigned to receive either the oral supplement combination or a comparator treatment. The study is single-blinded, meaning participants will not know which treatment they are receiving. Symptoms such as pain, numbness, and hand function will be assessed over a defined follow-up period using clinical evaluation and standardized questionnaires.

The main hypothesis of this study is that patients receiving the oral combination of alpha-lipoic acid, Vitamin E, and Vitamin B will experience greater improvement in symptoms and functional outcomes compared to those who do not receive the combination, without significant side effects.

The results of this study may help determine whether this oral supplement combination can be used as an effective and safe conservative treatment option for patients with Carpal Tunnel Syndrome, potentially reducing the need for invasive procedures.

Enrollment: 84 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age more than 18 years old
• Subjects with symptoms and physical examination of CTS
• Patients with CTS going for CT release

Exclusion criteria

• Pregnant or breast-feeding women
• Patients with history of trauma in the dominant hand

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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84 participants in 2 patient groups

Oral Antioxidant Supplement Group

Experimental group

Treatment:

Dietary Supplement: Alpha-Lipoic Acid, Vitamin E, and Vitamin B Complex

Control Group

Active Comparator group

Treatment:

Dietary Supplement: combination vitamin b1,b6 b12