A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)

Boehringer Ingelheim

Status and phase: Begins enrollment this month; Phase 2

Conditions: Liver Cirrhosis

Treatments: Drug: Placebo; Drug: BI 3802876

Study type: Interventional

Funder types: Industry

Identifiers

NCT07325526

1517-0002

1111-1313-8064 (Registry Identifier)

Details and patient eligibility

About

This study is open to adults with a type of confirmed liver condition called compensated cirrhosis due to Metabolic Dysfunction-Associated Steatohepatitis (MASH). The purpose of this study is to find out how well a study medicine called BI 3802876 is tolerated in people with this condition. The study looks at how different doses of BI 3802876 are handled by the body. BI 3802876 is being developed to improve liver health in people living with this liver condition.

Participants are put in 3 different dose groups randomly, which means by chance. Participants within a group get BI 3802876 or placebo. Placebo looks like BI 3802876 but does not contain any medicine. Participants have more than twice the chance of receiving BI 3802876 than placebo. The study medicine is given as an infusion into a vein.

Participants are in the study for about half a year. During this time, they visit the study site 12 times. At 2 visits, participants get the study medicine. Doctors collect information on any health problems and take blood samples to check how BI 3802876 is handled by the body. They compare results between the groups.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria :

• Male or female adults ≥18 to ≤75 years of age at the time of screening, and at least the legal age of consent in countries where it is > 18 years

• Patients meeting criteria for Child-Pugh category A without history of previous decompensation event

• Compensated Metabolic Dysfunction-Associated Steatohepatitis (MASH) cirrhosis diagnosed by 1 of the following:

  • Biopsy (collected during screening or ≤ 5 years* prior to screening) showing cirrhosis (fibrosis stage 4) with steatosis or steatohepatitis.

  • Biopsy (collected during screening or ≤ 5 years* prior to screening) showing cryptogenic cirrhosis.

  • Biopsy showing steatosis or steatohepatitis prior to screening without confirmation of fibrosis stage 4, or current or previous imaging showing steatosis with no liver histology available must meet either one of the following inclusion criteria at screening:

    1. Vibration-controlled transient elastography (VCTE) ≥ 15 kilopascals (kPa) plus 1 of the following, Magnetic Resonance Enterography (MRE) ≥4.2 kPa, platelet count <150,000/μL or imaging techniques (computed tomography (CT) scan and/or Magnetic Resonance Imaging (MRI) and/or Ultrasound) suggestive of cirrhosis.
    2. VCTE measurement ≥ 20 kPa
    3. Enhanced Liver Fibrosis (ELF) score ≥ 10.2 *If biopsy was collected > 365 days prior to screening either criteria a, b or c must be met Further inclusion criteria apply.

Exclusion Criteria :

• Patients with clinically significant portal hypertension defined by any of the following:

  • VCTE ≥25 kPa if the platelets are ≥150,000/μL
  • VCTE ≥20 kPa if platelets are <150,000/μL
  • History of esophageal or gastric varices (Grade ≥1) on endoscopy
  • ELF score ≥11.3
  • Hepatic venous pressure gradient (HVPG) ≥10 mmHg

• Other causes of liver disease based on medical history and/or centralized review of liver histology, including but not limited to alcoholic liver disease, autoimmune disorders (e.g., primary biliary cholangitis [PBC], primary sclerosing cholangitis [PSC], autoimmune hepatitis), drug-induced hepatotoxicity, Wilson disease, clinically significant iron overload, or alpha-1- antitryspin deficiency

• Chronic viral hepatitis parameters that would be considered exclusionary for the participation in this trial are (hepatitis B and C testing will be done at screening visit):

  • Hepatitis B virus (HBV): Past or present hepatitis B infection, including a positive hepatitis B surface antigen (HBsAg) and/or detectable HBV Deoxyribonucleic Acid (DNA).
  • Hepatitis C virus (HCV): patients with positive HCV ribonucleic acid (RNA). Patients treated for hepatitis C must have a negative RNA test at screening and be HCV RNA negative for at least 2 years prior to screening in order to be eligible for the trial.

• History of liver transplantation or patients listed for liver transplantation

• Suspicion, confirmed diagnosis, or history of Hepatocellular Carcinoma (HCC)

• Present or past evidence of decompensating events of liver cirrhosis

• Model for End-Stage Liver Disease (MELD) score > 12, unless due to therapeutic anti-coagulation

• History of significant alcohol consumption (defined as intake of > 210 g/week in males and > 140 g/week in females on average over a consecutive period of more than 3 months) within 1 year prior to screening

• International Normalized Ratio (INR) >1.3 unless due to therapeutic anticoagulants or laboratory error Further exclusion criteria apply.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Double Blind

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30 participants in 4 patient groups, including a placebo group

Placebo group

Placebo Comparator group

Treatment:

Drug: Placebo

Dose group 1

Experimental group

Treatment:

Drug: BI 3802876

Dose group 2

Experimental group

Treatment:

Drug: BI 3802876

Dose group 3

Experimental group

Treatment:

Drug: BI 3802876