A to Z Study Follow-up: Collection of DNA Data From Buccal Swabs

Interleukin Genetics

Status: Unknown

Conditions: Diet Conditions; Overweight Management; Dietary Recommendations; Obesity; Weight Management

Study type: Observational

Funder types: Industry

Identifiers

NCT00866151

14895

ILI-08-108WMGTP

Details and patient eligibility

About

The goal of this study is to determine the association between genotypes and diet. The weight and weight loss data are already available from the previously completed study called: A to Z Study - Benefits and Risks of Alternative Weight Loss Strategies - A Clinical Trial, which was performed from 2003-2005 at Stanford University. In the present study, Interleukin Genetics will obtain DNA samples from the previously enrolled study subjects to investigate genetic influence of the response to macronutrient compositions of low caloric diets to weight loss.

Full description

Interleukin Genetics has derived, through an extensive search of the scientific literature, a genetic test panel in the area of Weight Management (WM), which includes the genes that have been shown to affect body weight. These genes have been associated with elevated risk for obesity.

Enrollment: 150 estimated patients

Sex: Female

Ages: 25 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI (body mass index): 27-40 kg/m2
• Gender: Women only
• Age: 25-50
• Menopausal status: pre-menopausal
• Weight stable for last 2-months
• Not on a weight loss plan
• No ethnic restrictions
• No plans to move from the area over the next 6-months
• Willing to accept random assignment
• Possess English speaking and reading skills to understand and complete forms such as informed consent and study evaluation

Exclusion criteria

• Hypertension
• Diabetes (type 1 or 2) or history of gestational diabetes
• Heart disease diagnosis
• Renal or lever disease
• Active neoplasms
• Pregnant, lactating, within 6-months of birth, or planning to become pregnant in the next 6-months
• Hyperthyroidism, unless treated and under control
• Medications known to affect weight / energy expenditure
• Excessive alcohol intake (self-reported, > 3 drinks/day)
• Postmenopausal, including surgical menopause
• Currently under psychiatric care, or severely clinically depressed (>17 on Beck Inventory)

Trial design

150 participants in 1 patient group

1

Description:

Previously enrolled subjects in the "Benefits and Risks of Alternative Weight Loss Strategies - a Clinical Trial", which was run at Stanford 2003-2005. (A to Z Study)