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A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin

N

North Idaho Dermatology

Status

Completed

Conditions

Verruca Vulgaris

Treatments

Drug: Liquid nitrogen and topical placebo
Drug: Liquid nitrogen and cantharidin

Study type

Interventional

Funder types

Other

Identifiers

NCT01084824
NID-001

Details and patient eligibility

About

The purpose of the study was to see if liquid nitrogen, a commonly used treatment for warts, is more effective if it is used alone, or if it is more effective if combined with cantharidin, a topical treatment also commonly used for warts (verruca vulgaris).

Enrollment

70 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. common warts on non-genital, non-facial skin
  2. otherwise healthy
  3. between 18-65 and able to give informed consent
  4. capable of tolerating treatment

Exclusion criteria

  1. Ill-health
  2. Poor tolerance or sensitivity to treatments in study
  3. <18 years old; >65 years old
  4. verruca plana or condyloma acuminata
  5. immunosuppression or immune dysfunction
  6. significant peripheral vascular disease
  7. significant sensitivity to cold
  8. epidermodysplasia verruciformis
  9. mosaiform warts or periungual warts

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

70 participants in 2 patient groups, including a placebo group

Liquid nitrogen and canthardin
Active Comparator group
Description:
Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterwards.
Treatment:
Drug: Liquid nitrogen and cantharidin
Liquid nitrogen and placebo
Placebo Comparator group
Description:
Liquid nitrogen applied to wart(s) then placebo vehicle afterwards.
Treatment:
Drug: Liquid nitrogen and topical placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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