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About
This research study is studying radiation therapy as a possible treatment for meningioma or tumor on the lining of the brain. The study drug or intervention involved in this research study is Intensity Modulated Proton Therapy (IMPT)
Full description
This is a Phase I/II clinical trial. Researchers are trying to find out if using increased-dose intensity modulated proton therapy (IMPT) for treatment of Meningiomas will be more effective than the current treatment.
The intensity modulated part of IMPT allows for even better concentration of the radiation dose to the desired target and less dose to the surrounding normal tissues than even traditional passive scattering proton therapy can do. Proton beams can be regulated to stop within or shortly beyond treatment targets. Therefore there is little exposure of the normal tissue to radiation.
The FDA (the U.S. Food and Drug Administration) has not approved IMPT as a treatment for any disease.
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Inclusion criteria
Participants must have either:
OR
In the case of recurrent radiographically gross disease, pathologic diagnosis may be from time of original biopsy and/or surgery. Pathology should be reviewed and confirmed at the Participating Institution.
Patients may or may not have neurofibromatosis type 1 or 2.
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60 participants in 3 patient groups
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Central trial contact
Tarin Grillo; Helen A Shih, MD
Data sourced from clinicaltrials.gov
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