A Trial of Patients With a Charles Bonnet Syndrome (CBS)

Vienna Institute for Research in Ocular Surgery

Status: Completed

Conditions: Prevalence, Psychiatrist Intervention

Treatments: Other: interview

Study type: Interventional

Funder types: Other

Identifiers

NCT03148249

VIROS

Details and patient eligibility

About

Charles Bonnet Syndrome (CBS) is defined by the occurence of visual hallucinations (VH) in the absence of any mental disorder. Elderly patients with reduced visual acuity due to ophthalmic diseases are most affected. Conditions are often associated with the syndrome of age-related macular degeneration, cataract or glaucoma. Existing data on the syndrome's prevalence in Europe reveal diverse results. Aim of this study was to assess the prevalence of CBS in patients with low visual acuity and to evaluate, if an additional therapeutic interview with and treatment by a psychiatrist is beneficial.

Full description

Patients with a visual acuity of 0.5 LogMAR or less in the better eye were screened for CBS. Instruments used were an interview asking for details of the hallucinations, a mental test and a scale concerning quality of life. Patients with CBS were randomized by minimization in two groups: in group 1, a patient-doctor interview by an ophthalmologist was performed and in group 2 an interview and if needed, a therapy by a psychiatrist. At the 3-months follow up, the psychological strain of patients was recorded again.

Enrollment: 34 patients

Sex: All

Ages: 55 to 105 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• written informed consent
• visual acuity of 0.5 LogMAR or less at both eyes
• 55 years or older

Patients with CBS:

• have no mental pathologies such as dementia, psychosis or any other neurological diseases
• have a normal cognitive state
• are not able to control the VH
• know that the VH are not real
• are usually older
• have significantly reduced visual acuity due to an bilateral eye pathology

VH associated with CBS:

• disappear when the eyes are closed
• are repetitive
• are complex (eg. objects, geometrical patterns, faces, shapes, figures, scenes, animals or plants)

Exclusion criteria

• dopamine agonist medication
• temporal lobe epilepsy
• moderate to severe Alzheimer's dementia
• present chronic alcohol-/drug abuse
• bad cognitive state

There are no:

• auditory or olfactory hallucinations
• other abnormalities like delusions

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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34 participants in 2 patient groups

interview with an ophthalmologist

Experimental group

Description:

Patients get an interview with an ophthalmologist

Treatment:

Other: interview

interview/treatment by a psychiatrist

Experimental group

Description:

patients get an interview and a possible treatment by a psychiatrist

Treatment:

Other: interview