A Trial of Postoperative Whole Brain Radiation Therapy vs. Salvage Stereotactic Radiosurgery Therapy for Metastasis

Haruhiko Fukuda

Status and phase: Completed; Phase 3

Conditions: Neoplasm Metastasis; Brain Neoplasms

Treatments: Device: Salvage stereotactic radiosurgery arm; Device: Whole brain radiation therapy arm

Study type: Interventional

Funder types: Other

Identifiers

NCT00280475

JCOG0504

C000000307 (Registry Identifier)

Details and patient eligibility

About

The aim of this study is to evaluate non-inferiority of salvage stereotactic radiosurgery (SRS) in the patients who received surgical resection for brain metastases in comparison with postoperative whole brain radiation therapy (WBRT).

Full description

A randomized phase III study is started in Japan to compare postoperative whole brain radiation therapy with salvage stereotactic radiosurgery in patient with one to four brain metastases from lung, breast, and colorectal cancer.

Total of 270 patients will be accrued for this study from 21 institutions within three years. The primary endpoint is overall survival. The secondary endpoints are proportion of performance status (PS) preservation, proportion of mini-mental status examination (MMSE) preservation, and adverse events.

Enrollment: 270 patients

Sex: All

Ages: 20 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. one to four brain metastases with a maximum diameter of 3 cm or more for the largest lesion and additional lesions not exceeding 3 cm in diameter
2. all brain metastases localized within cerebrum or cerebellum
3. before surgical resection for brain metastasis, PS is 0-2, or 3 by cerebral nerve compression neurological deficits
4. surgical resection for the largest brain metastases has achieved
5. after surgical resection, four or fewer (0-4) residual lesions with maximum diameter under 3 cm
6. histologically proven non-small cell carcinoma, breast cancer or colorectal cancer
7. primary lesion and the other metastases (i.e. lung, liver, bone metastases except for brain) is consider to be controlled
8. an age of 20-79 years
9. no prior surgery or irradiation for brain
10. adequate organ function
11. written informed consent(If signing in consent form is difficult for the patient due to paralysis, signing by the family in place of the patient is permitted)

Exclusion criteria

1. synchronous or metachronous (within 5 years) malignancy other than carcinoma in situ or mucosal cancer
2. pregnant or breast-feeding women
3. severe mental disease
4. allergic to gadolinium contained contrast agents

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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270 participants in 2 patient groups

1

Active Comparator group

Description:

Device: Whole brain radiation therapy arm

Treatment:

Device: Whole brain radiation therapy arm

2

Experimental group

Description:

Device: Salvage stereotactic radiosurgery arm

Treatment:

Device: Salvage stereotactic radiosurgery arm