A Trial on Treatments of Hirschsprung Allied Disease

Tongji Hospital

Status: Enrolling

Conditions: Complication of Surgical Procedure; Complications of Treatment; Megacolon, Not Hirschsprung

Treatments: Behavioral: conservative; Procedure: operative

Study type: Interventional

Funder types: Other

Identifiers

NCT02212054

101

Details and patient eligibility

About

The present study was designed to compare the efficacy of conservative treatment to operative treatment for improvement of constipation symptoms in children with Hirschsprung allied disease

Full description

The present study was designed to compare the efficacy of conservative treatment,such as anal dilatation, colonic lavage and so on, to operative treatment for improvement of constipation symptoms in children with Hirschsprung allied disease

Enrollment: 50 estimated patients

Sex: All

Ages: 1 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hard or firm stools for twice or less per week
• a predicting score of less than 5 refer to literature: Wu, X.J., et al., A new diagnostic scoring system to differentiate Hirschsprung's disease from Hirschsprung's disease-allied disorders in patients with suspected intestinal dysganglionosis. Int J Colorectal Dis, 2013. 28(5): p. 689-96

Exclusion criteria

• functional constipation
• a predicting score of more than 5 refer to literature: Wu, X.J., et al., A new diagnostic scoring system to differentiate Hirschsprung's disease from Hirschsprung's disease-allied disorders in patients with suspected intestinal dysganglionosis. Int J Colorectal Dis, 2013. 28(5): p. 689-96

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

50 participants in 2 patient groups

conservative & operative treatment

Experimental group

Description:

anal dilation; colon lavage; probiotics

Treatment:

Behavioral: conservative

operative treatment

Active Comparator group

Description:

one stage pull- through radical colectomy

Treatment:

Procedure: operative